- •ROM training and PRT should be initiated earlier after BC surgery than guideline.
Main Outcome Measures
List of abbreviations:ALND (axillary lymph node dissection), ANOVA (Analysis of Variance), BC (breast cancer), CMS (Constant-Murley Score), D7R+W4P (Start ROM training at 7 days and PRT at 4 weeks postoperative), D7R+W3P (Start ROM training at 7 days and PRT at 3 weeks postoperative), D3R+W4P (Start ROM training at 3 days and PRT at 4 weeks postoperative), D3R+W3P (Start ROM training at 3 days and PRT at 3 weeks postoperative), EORTC QLQ-BR23 (European Organization Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module), PRT (progressive resistance training), QOL (quality of life), ROM (range of motion), SLNB (sentinel lymph node biopsy)
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AUTHOR CONTRIBUTIONS: Study conception and design: Qing Shu, Jun Tian; Intervention and assembly of data: Yuwei Shao, Hui Ten, Rong Liao, Zhengfa Li; Recruitment of participants: Jinxuan Hou, Gaosong Wu; Data management and analysis: Yanan Yang, Qing Shu; Supervision: Jun Tian; Writing original draft: Qing Shu; Writing review & editing: Qing Shu, Jun Tian, Yuwei Shao; All authors read and approved the final manuscript.
Ethics Statement The study protocol and informed consent form were approved by the Medical Ethics Committee of Zhongnan Hospital of Wuhan University in June 2018 (No. 2018013) (Sup.1). All participants gave written informed consent before data collection began. After finished the study, all inquiries about shoulder dysfunction after breast cancer surgery from participants would be properly addressed, or be directed to the corresponding specialist.
Registration: ClinicalTrials.gov NCT03658265.
Competing interests: We have no competing interests.