To examine the efficacy of Speed of Processing Training (SOPT) in improving everyday functional outcomes in persons with multiple sclerosis (MS).
Randomized controlled trial.
A nonprofit rehabilitation research institution and the community.
In total, 60 participants with MS with impaired processing speed were randomly assigned to SOPT (n=33) or an active control group (n=27).
SOPT, a restorative computerized cognitive intervention involving 10 treatment sessions consisting of visual tasks designed to improve speed and accuracy of information processing
Main Outcome Measures
Outcomes included performance on the Timed Instrumental Activities of Daily Living (TIADL) and self-report of functional behavior, quality of life, and affect.
The treatment group showed improvement in the total TIADL score and 2 subtests compared with the active control group. Participants in the treatment group who demonstrated improved cognitive performance after the intervention also showed improved performance on one TIADL subtest. Quality of life, affective symptomatology, and self-reported functional status were not changed after the intervention.
Improvement in underlying cognitive or perceptual deficits is thought to promote recovery and everyday performance as per the restorative approach to cognitive rehabilitation. However, this study showed only selected improvements in everyday functional outcomes for persons with MS.
List of abbreviations:ADL (activities of daily living), CMDI (The Chicago Multiscale Depression Inventory), MS (multiple sclerosis), PS (processing speed), QOL (quality of life), RCT (Randomized controlled trial), SOPT (Speed of Processing Training), STAI (State-Trait Anxiety Inventory), TIADL (Timed Instrumental Activities of Daily Living), η2partial (partial eta squared)
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Published online: February 07, 2023
Accepted: January 21, 2023
Received in revised form: January 11, 2023
Received: October 19, 2022
Publication stageIn Press Journal Pre-Proof
Clinical Trial Registration No.: NCT02301260.
Supported by National Multiple Sclerosis Society research grant #4997A5.
Disclosures: Dr DeLuca has financial relationships with Biogen IDEC, MedRhythms, Bristol Myers Squibb, Roche, and Janssen, outside the submitted work. The other authors have nothing to disclose.
© 2023 by the American Congress of Rehabilitation Medicine.