Abstract
Objective
To examine the efficacy of Speed of Processing Training (SOPT) in improving everyday
functional outcomes in persons with multiple sclerosis (MS).
Design
Randomized controlled trial.
Setting
A nonprofit rehabilitation research institution and the community.
Participants
In total, 60 participants with MS with impaired processing speed were randomly assigned
to SOPT (n=33) or an active control group (n=27).
Intervention
SOPT, a restorative computerized cognitive intervention involving 10 treatment sessions
consisting of visual tasks designed to improve speed and accuracy of information processing
Main Outcome Measures
Outcomes included performance on the Timed Instrumental Activities of Daily Living
(TIADL) and self-report of functional behavior, quality of life, and affect.
Results
The treatment group showed improvement in the total TIADL score and 2 subtests compared
with the active control group. Participants in the treatment group who demonstrated
improved cognitive performance after the intervention also showed improved performance
on one TIADL subtest. Quality of life, affective symptomatology, and self-reported
functional status were not changed after the intervention.
Conclusions
Improvement in underlying cognitive or perceptual deficits is thought to promote recovery
and everyday performance as per the restorative approach to cognitive rehabilitation.
However, this study showed only selected improvements in everyday functional outcomes
for persons with MS.
Keywords
List of abbreviations:
ADL (activities of daily living), CMDI (The Chicago Multiscale Depression Inventory), MS (multiple sclerosis), PS (processing speed), QOL (quality of life), RCT (Randomized controlled trial), SOPT (Speed of Processing Training), STAI (State-Trait Anxiety Inventory), TIADL (Timed Instrumental Activities of Daily Living), η2partial (partial eta squared)To read this article in full you will need to make a payment
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References
- Cognitive rehabilitation after severe acquired brain injury: current evidence and future directions.Neuropsychol Rehabil. 2018; 28: 879-898
- Thinking about the future cognitive remediation therapy—what works and could we do better?.Schizophr Bull. 2011; 37: S80-S90
- Enhancing brain plasticity to promote stroke recovery.Front Neurol. 2020; 11554089
- Brain plasticity and functional losses in the aged: scientific bases for a novel intervention.(editor)in: Møller AR Progress in brain research. Vol 157. Reprogramming of the brain. Elsevier, Amsterdam2006: 81-109
- Cognitive rehabilitation in children with attention deficit- hyperactivity disorder: transferability to untrained cognitive domains and behavior.Asian J Psychiatry. 2020; 49101949
- Evidenced-based cognitive rehabilitation for persons with multiple sclerosis: an updated review of the literature from 2007 to 2016.Arch Phys Med Rehabil. 2018; 99: 390-407
- Memory rehabilitation for people with multiple sclerosis.Cochrane Database Syst Rev. 2021; 10 (Oct 18)CD008754
- The role of speed versus working memory in predicting learning new information in multiple sclerosis.J Clin Exp Neuropsychol. 2013; 35: 180-191
- Information processing speed: Measurement issues and its relationships with other neuropsychological constructs.in: DeLuca J Kalmar JH Information processing speed in clinical populations. Psychology Press, New York2007
- Assessing everyday life functional activity using actual reality in persons with MS.Rehabil Psychol. 2018; 63: 276
- The relationship between neuropsychological measures and the Timed Instrumental Activities of Daily Living task in multiple sclerosis.Mult Scler Houndmills Basingstoke Engl. 2007; 13: 636-644
- Factors that moderate activity limitation and participation restriction in people with multiple sclerosis.Am J Occup Ther. 2015; 69 (6902260020p1)
- Unemployment in multiple sclerosis (MS): utility of the MS Functional Composite and cognitive testing.Mult Scler. 2014; 20: 112-115
- Current status of cognitive remediation for psychiatric disorders: a review.Front Psychiatry. 2018; 9: 461
- Effects of cognitive training interventions with older adults: a randomized controlled trial.JAMA. 2002; 288: 2271-2281
- Ten-year effects of the advanced cognitive training for independent and vital elderly cognitive training trial on cognition and everyday functioning in older adults.J Am Geriatr Soc. 2014; 62: 16-24
- The impact of speed of processing training on cognitive and everyday performance.Aging Ment Health. 2005; 9: 262-271
- A pilot study examining Speed of Processing Training (SPT) to improve processing speed in persons with multiple sclerosis.Front Neurol. 2018; 9: 685
- The efficacy of speed of processing training for improving processing speed in individuals with multiple sclerosis: a randomized clinical trial.J Neurol. 2022; 269: 3614-3624
- A new app for at-home cognitive training: description and pilot testing on patients with multiple sclerosis.JMIR MHealth UHealth. 2015; 3: e85
- Computerized cognitive rehabilitation for treatment of cognitive impairment in multiple sclerosis: an explorative study.J Integr Neurosci. 2020; 19: 341-347
- Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis.Ann Neurol. 2001; 50: 121-127
- Cognitive training decreases motor vehicle collision involvement of older drivers.J Am Geriatr Soc. 2010; 58: 2107-2113
- Timed instrumental activities of daily living tasks: relationship to cognitive function and everyday performance assessments in older adults.Gerontology. 2002; 48: 254-265
- Validation of the functional assessment of multiple sclerosis quality of life instrument.Neurology. 1996; 47: 129-139
- Documenting productive behaviors: using the functional behavior profile to plan discharge following stroke.J Gerontol Nurs. 2000; 26: 34-43
- The relation between subjective and objective measures of everyday life activities in persons with multiple sclerosis.Arch Phys Med Rehabil. 2005; 86: 2303-2308
- A health-related quality of life measure for multiple sclerosis.Qual Life Res. 1995; 4: 187-206
- Psychometric evaluation of the Chicago Multiscale Depression Inventory in multiple sclerosis patients.Mult Scler. 2003; 9: 160-170
- Manual for the Stait-Trait Anxiety Inventory.Consulting Psychologists Press, Inc, Palo Alto (CA)1983
- Anxiety in multiple sclerosis: psychometric properties of the State-Trait Anxiety Inventory.Acta Neurol Scand. 2016; 134: 458-466
- Beyond small, medium, or large: points of consideration when interpreting effect sizes.Educ Stud Math. 2019; 102: 1-8
- Evidence-based cognitive rehabilitation: systematic review of the literature from 2009 through 2014.Arch Phys Med Rehabil. 2019; 100: 1515-1533
- Efficacy of a computer-assisted cognitive rehabilitation intervention in relapsing-remitting multiple sclerosis patients: a multicenter randomized controlled trial.Behav Neurol. 2017; 2017: 1-17
- Adaptive vs. non-adaptive cognitive training by means of a personalized App: a randomized trial in people with multiple sclerosis.J NeuroEngineering Rehabil. 2016; 13: 88
- Cognitive rehabilitation: evidence-based interventions.in: Katz N Toglia J Cognition, occupation, and participation across the life span: neuroscience, neurorehabilitation, and models of intervention in occupational therapy. 4th ed. AOTA Press, North Bethesda (MD)2018: 51-68
- Rationale and description of BrainLevel: computerized repeated practice with strategy use instruction for children with acquired brain injury.Clin Rehabil. 2021; 35: 787-800
- The effectiveness of rehabilitation of cognitive-metacognitive strategies on dorsolateral frontal lobe functions in elderly.Aging Psychol. 2020; 6: 79-92
- A new generation computerised metacognitive cognitive remediation programme for schizophrenia (CIRCuiTS): a randomised controlled trial.Psychol Med. 2017; 47: 2720-2730
- The feasibility of a combined model of online interventions for adults with cancer-related cognitive impairment.Br J Occup Ther. 2021; 84: 430-440
- Computerized cognitive training in cognitively healthy older adults: A systematic review and network meta-analysis.MedRxiv. 2020; https://doi.org/10.1101/2020.10.07.20208306
- A randomized controlled trial to treat impaired learning and memory in multiple sclerosis: the self-GEN trial.Mult Scler. 2018; 24: 1096-1104
- Healthcare disruptions and use of telehealth services among persons with multiple sclerosis during the COVID-19 pandemic.Arch Phys Med Rehabil. 2022; 103: 1379-1386
- Differential impact of the COVID-19 pandemic on health care utilization disruption for community-dwelling individuals with and without acquired brain injury.Arch Rehabil Res Clin Transl. 2022; 4100176
- Does cognitive remediation for schizophrenia improve functional outcomes?.Curr Opin Psychiatry. 2013; 26: 151-157
Article info
Publication history
Published online: February 07, 2023
Accepted:
January 21,
2023
Received in revised form:
January 11,
2023
Received:
October 19,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
Clinical Trial Registration No.: NCT02301260.
Supported by National Multiple Sclerosis Society research grant #4997A5.
Disclosures: Dr DeLuca has financial relationships with Biogen IDEC, MedRhythms, Bristol Myers Squibb, Roche, and Janssen, outside the submitted work. The other authors have nothing to disclose.
Identification
Copyright
© 2023 by the American Congress of Rehabilitation Medicine.
