To evaluate the efficacy of different physical therapy interventions that could validate
decisions taken by health care providers in the field of haemophilic patients’ rehabilitation
according to the international classification of function (ICF) that contains; Body
Functions and Structures, Activity, and Participation.
Seven databases; PubMed, Cochrane library, Scopus, Web of science, Physiotherapy Evidence
Database (PEDro), Google scholar and Clinicaltrials.gov, were systematically searched
for randomized controlled trails (RCTs) evaluating any physical therapy modality to
After abstract and full-text filtration; a methodological quality assessment was performed
using the Physiotherapy Evidence Database (PEDro) scale for the studies that met the
Relevant data was extracted from eligible studies and outcomes were categorized according
to the ICF.
Using Review Manager® and Microsoft Excel®, a quantitative analysis using standardized
mean differences with the 95%CI was completed. Statistical heterogeneity between studies
was explored using the I2 test. The Fixed Effect Model was applied to all data analyses.
If heterogeneity was statistically significant, the Der Simonian and Laird random-effects
models were used instead.
35 RCTs with 1216 participants were included in this systematic review, 13 of them
dealt with paediatric patients. Most of the studies were of good quality while 12
studies were of low quality. Meta-analysis has shown significant difference in favour
of manual therapy, laser and therapeutic exercises on selected outcomes of body function
and structure, activity and participation categories of the ICF model.
This systematic review recommends using manual therapy and therapeutic exercise modalities
to improve join health status, in combination with the educational sessions to improve
the quality of life of patients with haemophilic arthropathy. For paediatrics with
haemophilic arthropathy, using laser therapy is promising for improving the functional