Abstract
Objective
To estimate the prevalence of neuropsychiatric disorders, including autism spectrum
disorders (ASDs), attention-deficit hyperactivity disorder (ADHD), depression, anxiety
disorders, and obsessive-compulsive disorder (OCD), in populations with Duchenne muscular
dystrophy (DMD) and Becker muscular dystrophy (BMD).
Data Sources
MEDLINE (via PubMed), Scopus, Web of Science, and Cochrane Library from inception
to November 2021.
Study Selection
Observational studies of individuals with DMD or BMD that estimated the prevalence
of ASDs, ADHD, depression, anxiety disorders, and OCD in each population.
Data Extraction
A random-effects meta-analysis was performed on each outcome and each population (ie,
DMD, BMD).
Data Synthesis
Twenty-three studies were included in the meta-analysis. In DMD, there was a prevalence
of 7.0% of ASDs, 18.0% of ADHD, 11.0% of depression, 24.0% of anxiety disorders, and
12.0% of OCD. Furthermore, in BMD, there was a prevalence of 6.0% of ASDs, 28.0% of
ADHD, 7.0% of depression, 25.0% of anxiety disorders, and 7.0% of OCD.
Conclusions
The prevalence of these neuropsychiatric disorders is higher among patients with DMD
or BMD than among the general population, and the presence of these disorders may
negatively influence optimal medical management.
List of abbreviations:
ADHD (attention-deficit hyperactivity disorder), ASD (autism spectrum disorder), BMD (Becker muscular dystrophy), CNS (central nervous system), DMD (Duchenne muscular dystrophy), OCD (obsessive-compulsive disorder)Keywords
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Article info
Publication history
Published online: July 12, 2022
Accepted:
May 17,
2022
Received in revised form:
May 7,
2022
Received:
January 11,
2022
Footnotes
C.P.M. is supported by a grant from the Universidad de Castilla-La Mancha (2018-CPUCLM-7939).
PROSPERO Registration No.: CRD42021274456.
Disclosures: none.
Identification
Copyright
© 2022 by the American Congress of Rehabilitation Medicine.
