Abstract
Objective
This systematic review analyzed the effects of physical exercise programs in patients
with cancer undergoing chemotherapy on chemotherapy-induced peripheral neuropathy
(CIPN) prevention.
Data Sources
PubMed, Web of Science, Scopus, and Cochrane Library were searched for relevant studies
published before December 2020. Additional references were identified by manual screening
of the reference lists.
Study Selection
Based on the Population, Intervention, Comparator, Outcomes, and Study Designs strategy,
randomized controlled trials in which physical exercise was applied before or during
chemotherapy to prevent or ameliorate CIPN were included.
Data Extraction
Two reviewers blinded and independent screened the articles, scored methodologic quality,
and extracted data for analysis. The review was conducted and reported according to
the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.
Sensitivity and precision analysis databases was included. Risk of bias assessment
and meta-analysis were conducted using the Cochrane tools.
Data Synthesis
Of 229 potentially relevant studies, 8 randomized controlled trials were included
and scored. They comprise a total of 618 patients with cancer. MEDLINE and Scopus
databases recorded the highest sensitivity. None of the studies achieved a “low” overall
risk of bias. Four studies were included in meta-analysis for quality of life, and
a significance standardized mean difference was found between groups from baseline
of 14.62; 95% CI, 6.03-3.20, with a large effect size g=0.83; 95% CI, 0.48-1.18) in favor of physical exercise program compared with usual
care.
Conclusions
Physical exercise at the onset of chemotherapy has shown promising effects on the
prevention of CIPN, specially improving quality of life.
Keywords
List of abbreviations:
CG (control group), CIPN (chemotherapy-induced peripheral neuropathy), FITT (frequency, intensity, time and type), IG (intervention group), RCT (randomized controlled trial), TOI (Trial Outcome Index)To read this article in full you will need to make a payment
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Article Info
Publication History
Published online: March 07, 2022
Accepted:
February 4,
2022
Received:
December 1,
2021
Footnotes
This work is part of M.L.G.'s doctoral work at the Clinical Medicine and Public Health Doctoral Studies of the University of Granada, Spain.
Supported by Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (FI19/00230) and by Ministerio Español de Educación Cultura y Deporte (FPU18/03575 and FPU17/00939).
Registration No. PROSPERO: CRD42020214356.
Disclosures: none.
Identification
Copyright
© 2022 by the American Congress of Rehabilitation Medicine.
