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Use and Costs of Nonprescription Medications Among People With Spinal Cord Injury

Published:February 07, 2022DOI:https://doi.org/10.1016/j.apmr.2021.12.030

      Abstract

      Objectives

      The study objectives were to assess the prevalence of, and factors associated with the use and costs of nonprescription medications among people with spinal cord injury.

      Design

      Observational design; a cross-sectional online survey.

      Setting

      Community in Canada.

      Participants

      Individuals with spinal cord injury (N=160).

      Interventions

      Not applicable.

      Main Outcome Measures

      Not applicable.

      Results

      A total of 160 individuals participated in this study. Of all study participants, 83% reported that they used at least 1 nonprescription medication over the last 12 months. On average, participants spent $52 per month on nonprescription medications. The average use and monthly expenditure did not differ significantly by age, sex, or injury parameters. Vitamins and minerals were most commonly used and constituted 62% of all nonprescription medications listed by the participants. Musculoskeletal issues were the most common health problems for which nonprescription medications were used.

      Conclusion

      Nonprescription medications are a common part of therapeutic drug regimens for people with spinal cord injuries and are purchased as an out-of-pocket expense. These products may or may not have established benefits. Knowledge about the use of nonprescription medications may help prescribers to improve drug safety, medication affordability, and quality of pharmacotherapy for patients with spinal cord injury.

      Keywords

      List of abbreviations:

      IP (Internet protocol)
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      References

        • Qato DM
        • Alexander GC
        • Conti RM
        • Johnson M
        • Schumm P
        • Lindau ST.
        Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States.
        JAMA. 2008; 300: 2867-2878
        • Kardas P
        • Urbański F
        • Lichwierowicz A
        • et al.
        The prevalence of selected potential drug-drug interactions of analgesic drugs and possible methods of preventing them: lessons learned from the analysis of the real-world national database of 38 million citizens of Poland.
        Front Pharmacol. 2021; 11: 1-10
        • Kim HJ
        • Yang YM
        • Choi EJ.
        Use patterns of over-the-counter (OTC) medications and perspectives on OTC medications among Korean adult patients with chronic diseases: gender and age differences.
        Patient Prefer Adherence. 2018; 12: 1597-1606
        • Masumoto S
        • Sato M
        • Maeno T
        • Ichinohe Y
        • Maeno T.
        Factors associated with the use of dietary supplements and over-the-counter medications in Japanese elderly patients.
        BMC Fam Pract. 2018; 19: 1-7
        • González-Stuart A.
        Herbal product use by older adults.
        Maturitas. 2011; 68: 52-55
        • Qato DM
        • Wilder J
        • Schumm LP
        • Gillet V
        • Alexander GC.
        Changes in prescription and over-the-counter medication and dietary supplement use among older adults in the United States, 2005 vs 2011.
        JAMA Intern Med. 2016; 176: 473-482
        • Bergien SO
        • Petersen CM
        • Lynning M
        • Kristiansen M
        • Skovgaard L.
        Use of natural medicine and dietary supplements concomitant with conventional medicine among people with multiple sclerosis.
        Mult Scler Relat Disord. 2020; : 44-53
        • Ghildayal N
        • Johnson PJ
        • Evans RL
        • Kreitzer MJ.
        Complementary and alternative medicine use in the US adult low back pain population.
        Glob Adv Heal Med. 2016; 5: 69-78
        • Greco CM
        • Nakajima C
        • Manzi S.
        Updated review of complementary and alternative medicine treatments for systemic lupus erythematosus.
        Curr Rheumatol Rep. 2013; 15: 1-9
        • Yang L
        • Sibbritt D
        • Adams J.
        A critical review of complementary and alternative medicine use among people with arthritis: a focus upon prevalence, cost, user profiles, motivation, decision-making, perceived benefits and communication.
        Rheumatol Int. 2017; 37: 337-351
        • Mohabbat AB
        • Mahapatra S
        • Jenkins SM
        • et al.
        Use of complementary and integrative therapies by fibromyalgia patients: a 14-year follow-up study.
        Mayo Clin Proc Innov Qual Outcomes. 2019; 3: 418-428
        • Currò D
        • Ianiro G
        • Pecere S
        • Bibbò S
        • Cammarota G.
        Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders.
        Br J Pharmacol. 2017; 174: 1426-1449
        • Lucke-Wold BP
        • Logsdon AF
        • Nguyen L
        • et al.
        Supplements, nutrition, and alternative therapies for the treatment of traumatic brain injury.
        Nutr Neurosci. 2018; 21: 79-91
        • McAlindon TE
        • LaValley MP
        • Gulin JP
        • Felson DT.
        Glucosamine and chondroitin for treatment of osteoarthritis.
        JAMA. 2000; 283: 1469-1475
        • Kris-Etherton PM
        • Harris WS
        • Appel LJ.
        Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease.
        Circulation. 2002; 106: 2747-2757
        • Honig PK
        • Gillespie BK.
        Drug interactions between prescribed and over-the-counter medication.
        Drug Safety. 1995; 13: 296-303
        • Yoon SL
        • Schaffer SD.
        Herbal, prescribed, and over-the-counter drug use in older women: prevalence of drug interactions.
        Geriatr Nurs (Minneap). 2006; 27: 118-129
        • Rolita L
        • Freedman M.
        Over-the-counter medication use in older adults.
        J Gerontol Nurs. 2008; 34: 8-17
        • Souty C
        • Launay T
        • Steichen O
        • et al.
        Use of the French healthcare insurance database to estimate the prevalence of exposure to potential drug-drug interactions.
        Eur J Clin Pharmacol. 2020; 76: 1675-1682
        • Moore N
        • Pollack C
        • Butkerait P.
        Adverse drug reactions and drug-drug interactions with over-the-counter NSAIDs.
        Ther Clin Risk Manag. 2015; 11: 1061-1075
        • Poon IO
        • Skelton F
        • Bean LR
        • et al.
        Building community-engaged multidisciplinary partnerships to improve medication management in elderly patients with multiple chronic conditions.
        J Patient-Centered Res Rev. 2021; 8: 113-120
        • Anoopkumar-Dukie S
        • Mey A
        • Hall S
        • Bernaitis N
        • Davey AK
        • Plummer D.
        Non-prescription medicines may contribute to non-adherence to prescription medicines in people living with chronic health conditions.
        Int J Clin Pract. 2020; 74: 1-12
        • Gupta S
        • McColl MA
        • Smith K
        • Guilcher SJT.
        Prescription medication cost, insurance coverage, and cost-related nonadherence among people with spinal cord injury in Canada.
        Spinal Cord. 2020; 58: 587-595
        • Gupta S
        • McColl MA
        • Smith K
        • McColl A.
        Prescribing patterns for treating common complications of spinal cord injury.
        J Spinal Cord Med. 2021 May 6. [Epub ahead of print]; : 1-9
        • Gupta S
        • McColl MA
        • Guilcher S
        • Smith K.
        Cost-related nonadherence to prescription medications in Canada: a scoping review.
        Patient Prefer Adherence. 2018; 12: 1699-1715
        • Farry A
        • Baxter D.
        The incidence and prevalence of spinal cord injury in Canada: overview and estimates based on current evidence.
        Rick Hansen Institue and Urban Futures, Ontario, Canada2010
        • Charan J
        • Biswas T.
        How to calculate sample size for different study designs in medical research?.
        Indian J Psychol Med. 2013; 35: 121-126
      1. The University of Maryland Health Partners. Over-the-counter drug list. 2017. Available at: https://www.carefirstchpmd.com/wp-content/uploads/2016/09/UMHP-OTC-List-0417-38527-fmt-usec.pdf. Accessed March 6, 2022.

      2. Canada Minister of Justice. Cannabis Act/Loi sur Cannabis. 2018. Available at: https://laws-lois.justice.gc.ca/pdf/C-24.5.pdf. Accessed March 8, 2022.

        • Mishra S
        • Stierman B
        • Gahche JJ
        • Potischman N.
        Dietary supplement use among adults: United States, 2017-2018.
        NCHS Data Brief. 2021;
      3. Statistics Canada. Health Statistics Division. Use of nutritional supplements, 2015. Available at: https://www.statcan.gc.ca/pub/82-625-x/2017001/article/14831-eng.htm. Accessed October 19, 2020.

        • Sezer N
        • Akkuş S
        • Uğurlu FG.
        Chronic complications of spinal cord injury.
        World J Orthop. 2015; 6: 24-33
        • Michailidou C
        • Marston L
        • De Souza LH
        • Sutherland I.
        A systematic review of the prevalence of musculoskeletal pain, back and low back pain in people with spinal cord injury.
        Disabil Rehabil. 2014; 36: 705-715
        • Cardenas DD
        • Jensen MP.
        Treatments for chronic pain in persons with spinal cord injury: a survey study.
        J Spinal Cord Med. 2006; 29: 109-117
        • Ford K
        • Whiting SJ.
        Vitamin and mineral supplement use by community-dwelling adults living in Canada and the United States: a scoping review.
        J Diet Suppl. 2018; 15: 419-430
        • Opperman EA
        • Buchholz AC
        • Darlington GA
        • Martin Ginis KA
        Dietary supplement use in the spinal cord injury population.
        Spinal Cord. 2010; 48: 60-64
        • Flueck JL
        • Perret C.
        Vitamin D deficiency in individuals with a spinal cord injury: a literature review.
        Spinal Cord. 2017; 55: 428-434
        • Petchkrua W
        • Burns SP
        • Stiens SA
        • James JJ
        • Little JW.
        Prevalence of vitamin B12 deficiency in spinal cord injury.
        Arch Phys Med Rehabil. 2003; 84: 1675-1679
        • Javidan AN
        • Sabour H
        • Latifi S
        • et al.
        Calcium and vitamin D plasma concentration and nutritional intake status in patients with chronic spinal cord injury: a referral center report.
        J Res Med Sci. 2014; 19: 881-884
        • Dionyssiotis Y.
        Malnutrition in spinal cord injury: more than nutritional deficiency.
        J Clin Med Res. 2012; 4: 227-236
        • Cook N
        • Coggigan F
        • van den Heuvel C.
        The role of magnesium in CNS injury.
        (editors)in: Vink R Nechifor M Magnesium in the central nervous system. The University of Adelaide Press, Griffin Press, South Australia2011: 167-180
        • Pannek J
        • Pannek-Rademacher S
        • Wöllner J.
        Use of complementary and alternative medicine in persons with spinal cord injury in Switzerland: a survey study.
        Spinal Cord. 2015; 53: 569-572
        • Wong S
        • Graham A
        • Green D
        • Hirani SP
        • Forbes A.
        Nutritional supplement usage in patients admitted to a spinal cord injury center.
        J Spinal Cord Med. 2013; 36: 645-651
        • Plotnikoff GA
        • Quigley JM.
        Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain.
        Mayo Clin Proc. 2003; 78: 1463-1470
        • Round AM
        • Joo MC
        • Barakso CM
        • et al.
        Neurogenic bowel in acute rehabilitation following spinal cord injury: impact of laxatives and opioids.
        J Clin Med. 2021; 10: 1673-1686
        • Paré P
        • Fedorak RN.
        Systematic review of stimulant and nonstimulant laxatives for the treatment of functional constipation.
        Can J Gastroenterol Hepatol. 2014; 28: 549-557
        • Ylä-Rautio H
        • Siissalo S
        • Leikola S.
        Drug-related problems and pharmacy interventions in non-prescription medication, with a focus on high-risk over-the-counter medications.
        Int J Clin Pharm. 2020; 42: 786-795
        • Noreau L
        • Noonan VK
        • Cobb J
        • Leblond J
        • Dumont FS.
        Spinal cord injury community survey: understanding the needs of Canadians with SCI.
        Top Spinal Cord Inj Rehabil. 2014; 20: 265-276
        • Goodman N
        • Jette AM
        • Houlihan B
        • Williams S.
        Computer and internet use by persons after traumatic spinal cord injury.
        Arch Phys Med Rehabil. 2008; 89: 1492-1498
        • Mayman G
        • Perera M
        • Meade MA
        • Jennie J
        • Maslowski E
        Electronic device use by individuals with traumatic spinal cord injury.
        J Spinal Cord Med. 2017; 40: 449-455