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Research Objectives
To evaluate gender differences in cognitive function and physiological outcomes associated
with physical function on the Cerebral Palsy Adult Transition Study (CPAT) cohort.
Design
Cross-sectional, cohort, study.
Setting
Accredited clinical motion analysis laboratory at a regional Children's Hospital.
Participants
72 ambulatory adults with CP [mean ± SD of age= 20± 5.3] representing a balanced gender
sample (38 females and 34 males).
Interventions
N/A.
Main Outcome Measures
Physiological outcomes included BMI, waist-to-hip ratio, grip strength and rate of
force development (RFD). An instrumented gait analysis was utilized to assess walking
ability, in which Gait Deviation Index and walking speed adjusted for height were
collected. Cognitive function was evaluated using the WMS-IV and the WAIS- IV subtests.
Blood biomarkers consisted of glucose, insulin, lipids (CHOL, HDL, Non-HDL, LDL) and
BDNF. Simple T-tests were performed to determine differences between females and males.
Results
Grip strength (p-value = 0.006) showed differences between females and males, in which
males showing higher scores. For cognitive function, differences were observed within
the WMS-IV subtests; Visual Reproduction delayed recall (p-value = 0.0252) and delayed
recognition (p-value = 0.0498), in which females had higher scores compared to males.
For the blood biomarkers, only BDNF (p-value =0.02) and HDL (p-value =0.0003) showed
differences, in which females showing the highest levels. There were no differences
in walking performance between females and males.
Conclusions
The analysis showed that there is gender-specific health outcome differences in adults
with CP. Physiological and biological markers are important to guide precision medicine
models. Biomarkers can generate diagnosis and treatments accordingly to patient unique
health needs. As such, it could assist clinicians to accurately differentiate those
at risk for disease as well as to design disease-modifying interventions.
Author(s) Disclosures
There is no conflict of interest.
Keywords
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© 2022 Published by Elsevier Inc.
