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Research Objectives
Adults with cerebral palsy (CP) have higher risk of developing geriatric syndromes.
Mild cognitive impairment (MCI) is an intermediate stage between healthy aging and
dementia, often co-morbid with cardiovascular disease (CVD). We recently showed an
“accelerated aging model”, where CP shares similar CVD risk factors with MCI, potentially
accounting for CP's increased risk of dementia. In this study, we further examined
sex differences between CP and MCI (aim 1) and within CP (aim 2).
Design
Cross-sectional study.
Setting
An accredited clinical motion analysis laboratory at Children's Hospital Colorado
(CP) and a university in Singapore (MCI).
Participants
72 adults with CP [mean (SD) of age=20 (5.3), Sex: men=47.2% and women=52.8%] and
MCI [mean (SD) of age=71.28 (6.03), Sex: men=29.2% and women=70.8%]. We analyzed blood
Pressure (BP), Framingham Heart Study Score (FHSS), and brain-derived neurotrophic
factor (BDNF).
Interventions
N/A.
Main Outcome Measures
Blood Pressure (Bp), Framingham Heart Study Score (FHSS), and brain-derived neurotrophic
factor (BDNF) biomarker analyses were conducted. To address aim 1; BDNF and the FHSS
were compared between CP and MCI using regression analyses, stratified by sex. For
aim 2, regression analyses were performed to compare men and women outcomes within
CP. Confounding effects of age and years of education were controlled in the analysis.
Results
Compared to MCI, women with CP had lower BDNF (β=-3.550, 95% CI=-5.659 to -1.441,
p=0.001), while men with CP had lower diastolic Bp (β=-28.204, 95% CI=-52.148 to -4.260,
p=0.022). Both women and men with CP also had lower FHSS as compared to MCI (β=-2.515,
95% CI=-3.721 to -1.309, p<0.001; β=-3.724, 95% CI=-5.561 to -1.888, p<0.001, respectively).
Women in the CP cohort showed lower FHSS (β=-0.172, 95% CI=-0.310 to -0.033, p=0.016).
Conclusions
We found sex-related differences in BDNF and CVD markers. Comparing across and within
cohorts, although having lower BDNF levels, women with CP had better FHSS. These findings
support our accelerated aging hypothesis, and further suggest sex differences in aging-related
risk factors in CP, supporting sex-related precision medicine approach.
Author(s) Disclosures
None.
Keywords
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© 2022 Published by Elsevier Inc.
