Abstract
Objective
To determine whether true interindividual response differences (IIRD) exist with respect
to changes in anxiety because of aerobic exercise training in adults with fibromyalgia
(FM).
Data Sources
Data from a previous meta-analytical database of randomized controlled trials of exercise
in adults with arthritis and other rheumatic diseases.
Study Selection
Randomized controlled trials limited to aerobic exercise training on anxiety in adults
18 years or older with FM were included.
Data Extraction
Change outcome SDs treated as point estimates for anxiety were used to calculate true
IIRD from each study. In addition, treatment effect data were extracted.
Data Synthesis
The inverse variance heterogeneity model was used to pool all results. For the 5 studies
and 321 participants in which results were pooled, statistically significant treatment
effect reductions in anxiety were observed (mean, −0.77 points, 95% CI, −1.25 to −0.77).
However, no significant IIRD were found (mean, 0.6 points, 95% CI, −1.2 to 1.5). The
95% prediction interval for true IIRD in a future study was −1.7 to 0.8. The percent
chance, ie, probability, of a clinically meaningful difference in variability, was
61.5% (only possibly clinically important).
Conclusions
The results of the current study suggest that aerobic exercise is associated with
reductions in anxiety among adults with fibromyalgia. However, there is currently
a lack of convincing evidence to support the notion that true IIRD exist. Therefore,
a search for potential mediators and moderators associated with aerobic exercise and
changes in anxiety among adults with FM may not be warranted. However, additional
research is needed before any true level of certainty can be established. This includes
(1) the assessment of IIRD in future randomized controlled trials, (2) randomized
controlled trials of longer duration, and (3) an increase in the proportion of men
included in randomized controlled trials.
Keywords
List of abbreviations:
FM (fibromyalgia), GRADE (Grading of Recommendations Assessment, Development, and Evaluation), IIRD (interindividual response difference), MCID (minimal clinically important difference), NNT (number needed to treat), PI (prediction interval)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: January 16, 2022
Accepted:
December 23,
2021
Received in revised form:
November 12,
2021
Received:
June 17,
2021
Footnotes
Supported in part by the National Institutes of Health, National Institute for Arthritis, Musculoskeletal and Skin Diseases, grant no. R01AR061346 (G.A.K., Principal Investigator). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Disclosures: none.
Identification
Copyright
© 2022 by the American Congress of Rehabilitation Medicine.
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- CorrectionArchives of Physical Medicine and RehabilitationVol. 104Issue 1
- PreviewIn the article, “Are There Interindividual Differences in Anxiety as a Result of Aerobic Exercise Training in Adults With Fibromyalgia? An Ancillary Meta-analysis of Randomized Controlled Trials” ( https://www.archives-pmr.org/article/S0003-9993(22)00007-7/fulltext ), the 95% confidence interval in the second sentence of the Data Synthesis section of the abstract should be “−1.25 to −0.29”. Also, in the first row of Table 1, the 95% confidence interval likewise should be “−1.25 to −0.29”.
- Full-Text
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