Advertisement
SPECIAL COMMUNICATION| Volume 103, ISSUE 3, P574-580, March 2022

Demystifying the Complexity of Aphasia Treatment: Application of the Rehabilitation Treatment Specification Systemx

Published:November 05, 2021DOI:https://doi.org/10.1016/j.apmr.2021.08.025

      Abstract

      A considerable body of research supports the use of behavioral communication treatment as the standard of care for aphasia. In spite of robust progress in clinical aphasiology, many questions regarding optimal care remain unanswered. One of the major challenges to progress in the field is the lack of a common framework to adequately describe individual treatments, which, if available, would allow comparisons across studies as well as improved communication among researchers, clinicians, and other stakeholders. Here, we describe how aphasia treatment approaches can be systematically characterized using the Rehabilitation Treatment Specification System (RTSS). At the core of the RTSS is a tripartite structure that focuses on targets (the behavior that is expected to change as a result of treatment), ingredients (what a clinician does to affect change in the target), and mechanism(s) of action (why a given treatment works by linking the ingredients to the target). Three separate articles in the current issue specifically describe how the RTSS can be used to describe different kinds of aphasia treatment approaches: functional approaches, cognitive-linguistic approaches, and biological approaches. It is our hope that the application of the RTSS in clinical aphasiology will improve communication in published studies, grant proposals, and in the clinical care of persons with aphasia.

      List of abbreviations:

      MOA (mechanism of action), RTSS (Rehabilitation Treatment Specification System), SLP (speech-language pathologist), TUF (Treatment of Underlying Forms)

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Archives of Physical Medicine and Rehabilitation
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Fama ME
        • Turkeltaub PE.
        Treatment of poststroke aphasia: current practice and new directions.
        Semin Neurol. 2014; 34: 504-513
        • Dejerine J
        • Thomas A.
        Language restoration in Broca’s aphasia: two cases with autopsy.
        Nouvelle Iconographie de la Salpêtrière. 1914; xxvi: 331-357
        • Mills CK.
        Treatment of aphasia by training.
        JAMA. 1904; 43: 1940-1949
        • David R
        • Enderby P
        • Bainton D.
        Treatment of acquired aphasia: speech therapists and volunteers compared.
        J Neurol Neurosurg Psychiatry. 1982; 45: 957-961
        • Greener J
        • Enderby P
        • Whurr R.
        Speech and language therapy for aphasia following stroke.
        Cochrane Database Syst Rev. 2000; 2CD000425
        • Holland AL
        • Fromm DS
        • DeRuyter F
        • Stein M.
        Treatment efficacy: aphasia.
        J Speech Hear Res. 1996; 39: S27-S36
        • Nouwens F
        • de Lau LM
        • Visch-Brink EG
        • et al.
        Efficacy of early cognitive-linguistic treatment for aphasia due to stroke: a randomised controlled trial (Rotterdam Aphasia Therapy Study-3).
        Eur Stroke J. 2017; 2: 126-136
        • Laska AC
        • Kahan T
        • Hellblom A
        • Murray V
        • von Arbin M.
        A randomized controlled trial on very early speech and language therapy in acute stroke patients with aphasia.
        Cerebrovasc Dis Extra. 2011; 1: 66-74
        • Lincoln NB
        • McGuirk E
        • Mulley GP
        • Lendrem W
        • Jones AC
        • Mitchell JR.
        Effectiveness of speech therapy for aphasic stroke patients. A randomised controlled trial.
        Lancet. 1984; 1: 1197-1200
        • Schoonen R.
        The internal validity of efficacy studies: design and statistical power in studies of language therapy for aphasics.
        Brain Lang. 1991; 41: 446-464
        • Hartman J
        • Landau WM.
        Comparison of formal language therapy with supportive counseling for aphasia due to acute vascular accident.
        Arch Neurol. 1987; 44: 646-649
        • Robey RR.
        The efficacy of treatment for aphasic persons: a metaanalysis.
        Brain Lang. 1994; 47: 582-608
        • Robey RR.
        A meta-analysis of clinical outcomes in the treatment of aphasia.
        J Speech Lang Hear Res. 1998; 41: 172-187
        • Brady MC
        • Kelly H
        • Godwin J
        • Enderby P.
        Speech and language therapy for aphasia following stroke.
        Cochrane Database of Syst Rev. 2012; 5CD000425
        • Brady MC
        • Kelly H
        • Godwin J
        • Enderby P
        • Campbell P.
        Speech and language therapy for aphasia following stroke.
        Cochrane Database Syst Rev. 2016; 6CD000425
        • Breitenstein C
        • Grewe T
        • Floel A
        • et al.
        Intensive speech and language therapy in patients with chronic aphasia after stroke: a randomised, open-label, blinded-endpoint, controlled trial in a health-care setting.
        Lancet. 2017; 389: 1528-1538
        • Shrubsole K
        • Worrall L
        • Power E
        • DA O'Connor
        Priorities for closing the evidence-practice gaps in poststroke aphasia rehabilitation: a scoping review.
        Arch Phys Med Rehabil. 2018; 99: 1413-1423
        • Darley FL.
        The efficacy of language rehabilitation in aphasia.
        J Speech Hear Disord. 1972; 37: 3-21
        • Kiran S.
        How does severity of aphasia influence individual responsiveness to rehabilitation?.
        Semin Speech Lang. 2016; 37 (Using big data to understand theories of aphasia rehabilitation): 48-60
        • Elman RJ
        • Bernstein-Ellis E.
        The efficacy of group communication treatment in adults with chronic aphasia.
        J Speech Lang Hear Res. 1999; 42: 411-419
        • Edmonds LA
        • Nadeau SE
        • Kiran S.
        Effect of Verb Network Strengthening Treatment (VNeST) on lexical retrieval of content words in sentences in persons with aphasia.
        Aphasiology. 2009; 23: 402-424
        • Edmonds LA
        • Babb M.
        Effect of Verb Network Strengthening Treatment in moderate-to-severe aphasia.
        Am J Speech Lang Pathol. 2011; 20: 131-145
        • Lee JB
        • Kaye RC
        • Cherney LR.
        Conversational script performance in adults with non-fluent aphasia: treatment intensity and aphasia severity.
        Aphasiology. 2009; 23: 885-897
        • Persad C
        • Wozniak L
        • Kostopoulos E.
        Retrospective analysis of outcomes from two intensive comprehensive aphasia programs.
        Top Stroke Rehabil. 2013; 20: 388-397
        • Godecke E
        • Hird K
        • Lalor EE
        • Rai T
        • Phillips MR.
        Very early poststroke aphasia therapy: a pilot randomized controlled efficacy trial.
        Int J Stroke. 2012; 7: 635-644
        • Edmonds LA
        • Obermeyer J
        • Kernan B.
        Investigation of pretreatment sentence production impairments in individuals with aphasia: towards understanding the linguistic variables that impact generalisation in Verb Network Strengthening Treatment.
        Aphasiology. 2015; 29: 1312-1344
        • Penaloza C
        • Barrett K
        • Kiran S.
        The influence of prestroke proficiency on poststroke lexical-semantic performance in bilingual aphasia.
        Aphasiology. 2020; 34: 1223-1240
        • Meier EL
        • Johnson JP
        • Pan Y
        • Kiran S.
        The utility of lesion classification in predicting language and treatment outcomes in chronic stroke-induced aphasia.
        Brain Imaging Behav. 2019; 13: 1510-1525
        • Lacey EH
        • Skipper-Kallal LM
        • Xing SH
        • Fama ME
        • Turkeltaub PE.
        Mapping common aphasia assessments to underlying cognitive processes and their neural substrates.
        Neurorehabil Neural Repair. 2017; 31: 442-450
        • Campbell M
        • Fitzpatrick R
        • Haines A
        • et al.
        Framework for design and evaluation of complex interventions to improve health.
        Br Med J. 2000; 321: 694-696
        • O'Cathain A
        • Croot L
        • Duncan E
        • et al.
        Guidance on how to develop complex interventions to improve health and healthcare.
        BMJ Open. 2019; 9: 9
        • Dipper LT
        • Franklin S
        • de Aguiar V
        • et al.
        An umbrella review of aphasia intervention description in research: the AsPIRE project.
        Aphasiology. 2021; : 26
        • Negrini S
        • Armijo-Olivo S
        • Patrini M
        • et al.
        The randomized controlled trials rehabilitation checklist methodology of development of a reporting guideline specific to rehabilitation.
        Am J Phys Med Rehabil. 2020; 99: 210-215
        • Wilson SM
        • Schneck SM.
        Neuroplasticity in post-stroke aphasia: a systematic review and meta-analysis of functional imaging studies of reorganization of language processing.
        Neurobiol Lang. 2021; 2: 22-82
        • Ballard KJ
        • Thompson CK.
        Treatment and generalization of complex sentence production in agrammatism.
        J Speech Lang Hear Res. 1999; 42: 690-707
      1. Hart T WJ, Dijkers M, Packel A, et al. Manual of rehabilitation treatment specification. Available at: https://acrm.org/wp-content/uploads/2019/02/Manual_Treatment_Specification_v6.2_confidential.pdf. Accessed June 18, 2021.

        • Albert ML
        • Sparks R.
        • Helm N.
        Melodic intonation treatment for aphasia.
        Arch Neurol. 1988; 29: 130-131
        • Sparks R
        • Helm N
        • Albert M.
        Aphasia rehabilitation resulting from melodic intonation therapy.
        Cortex. 1974; 10: 303-316
        • Hart T
        • Dijkers MP
        • Whyte J
        • et al.
        A theory-driven system for the specification of rehabilitation treatments.
        Arch Phys Med Rehabil. 2019; 100: 172-180
        • Pierce JE
        • O'Halloran R
        • Menahemi-Falkov M
        • Togher L
        • Rose ML.
        Comparing higher and lower weekly treatment intensity for chronic aphasia: a systematic review and meta-analysis.
        Neuropsychol Rehabil. 2021; 31: 1289-1313
        • Cherney LR
        • Patterson JP
        • Raymer AM.
        Intensity of aphasia therapy: evidence and efficacy.
        Curr Neurol Neurosci Rep. 2011; 11: 560-569
        • Simmons-Mackie N
        • Damico JS
        • Damico HL.
        A qualitative study of feedback in aphasia treatment.
        Am J Speech Lang Pathol. 1999; 8: 218-230
        • Hamilton RH
        • Chrysikou EG
        • Coslett B.
        Mechanisms of aphasia recovery after stroke and the role of noninvasive brain stimulation.
        Brain Lang. 2011; 118: 40-50
        • Berthier ML
        • Pulvermüller F.
        • Dávila G
        • Casares NG
        • Gutiérrez A
        Drug treatment of post-stroke aphasia: a review of current evidence.
        Neuropsychol Rev. 2011; 21: 302
        • Cotelli M
        • Manenti R
        • Ferrari C
        • Gobbi E
        • Macis A
        • Cappa SF.
        Effectiveness of language training and non-invasive brain stimulation on oral and written naming performance in primary progressive aphasia: a meta-analysis and systematic review.
        Neurosci Biobehav Rev. 2020; 108: 498-525
        • Otal B
        • Olma MC
        • Floel A
        • Wellwood I.
        Inhibitory non-invasive brain stimulation to homologous language regions as an adjunct to speech and language therapy in post-stroke aphasia: a meta-analysis.
        Front Hum Neurosci. 2015; 9: 236
        • Ren CL
        • Zhang GF
        • Xia N
        • et al.
        Effect of low-frequency rTMS on aphasia in stroke patients: a meta-analysis of randomized controlled trials.
        PLoS One. 2014; 9e102557
        • Fridriksson J
        • Holland AL
        • Beeson P
        • Morrow L.
        Spaced retrieval treatment of anomia.
        Aphasiology. 2005; 19: 99-109
        • Gravier ML
        • Dickey MW
        • Hula WD
        • et al.
        What matters in semantic feature analysis: practice-related predictors of treatment response in aphasia.
        Am J Speech Lang Pathol. 2018; 27: 438-453
        • Martin N
        • Fink R
        • Laine M.
        Treatment of word retrieval deficits with contextual priming.
        Aphasiology. 2004; 18: 457-471
        • Raymer A
        • Kohen F.
        Word-retrieval treatment in aphasia: effects of sentence context.
        J Rehabil Res Dev. 2006; 43: 367-378
        • Wisenburn B
        • Mahoney K.
        A meta-analysis of word-finding treatments for aphasia.
        Aphasiology. 2009; 23: 1338-1352
        • Dietz A
        • Wallace SE
        • Weissling K.
        Revisiting the role of augmentative and alternative communication in aphasia rehabilitation.
        Am J Speech Lang Pathol. 2020; 29: 909-913
        • Edmonds LA
        • Mammino K
        • Ojeda J.
        Effect of Verb Network Strengthening Treatment (VNeST) in persons with aphasia: extension and replication of previous findings.
        Am J Speech Lang Pathol. 2014; 23: 312-329
        • Beeke S
        • Beckley F
        • Johnson F
        • et al.
        Conversation focused aphasia therapy: investigating the adoption of strategies by people with agrammatism.
        Aphasiology. 2015; 29: 355-377
        • Code C.
        Significant landmarks in the history of aphasia and its treatment In.
        in: Papathanasiou I Coppens P Aphasia and related communication disorders. 2nd ed. Jones & Bartlett, Burlington, MA2017
        • Linebaugh CW
        • Lehner LH.
        Cueing hierarchies and word retrieval: a therapy program.
        George Washington University and Medical Center, Washington (DC)1977: 19-31
        • Patterson JP.
        The effectiveness of cueing hierarchies as a treatment for word retrieval impairment.
        Perspect Neurophysiol Neurogenic Speech Lang Disord. 2001; 11: 11-18
        • Nickels L
        • Best W
        • Howard D.
        Optimising the ingredients for evaluation of the effects of intervention.
        Aphasiology. 2015; 29: 619-643
        • Helm-Estabrooks N
        • Fitzpatrick PM
        • Barresi B.
        Visual action therapy for global aphasia.
        J Speech Hear Disord. 1982; 47: 385-389
        • Conlon CP
        • McNeil MR.
        The efficacy of treatment for two globally aphasic adults using visual action treatment.
        Clinical aphasiology. 1991: 185-195
        • Quique YM
        • Evans WS
        • Dickey MW.
        Acquisition and generalization responses in aphasia naming treatment: a meta-analysis of semantic feature analysis outcomes.
        Am J Speech Lang Pathol. 2019; 28: 230-246
        • Hersh D
        • Worrall L
        • Howe T
        • Sherratt S
        • Davidson B.
        SMARTER goal setting in aphasia rehabilitation.
        Aphasiology. 2012; 26: 220-233
        • Biel M
        • Nitta L
        • Jackson C.
        • Coppens P
        • Patterson J
        Understanding motivation in aphasia rehabilitation.
        Aphasia rehabilitation: clinical challenges. Jones & Barlett Learning, Burlington, MA2018: 393-436
        • Whyte J
        • Dijkers MP
        • Hart T
        • et al.
        The importance of voluntary behavior in rehabilitation treatment and outcomes.
        Arch Phys Med Rehabil. 2019; 100: 156-163
        • Ashaie SA
        • Hurwitz R
        • Cherney LR.
        Depression and subthreshold depression in stroke-related aphasia.
        Arch Phys Med Rehabil. 2019; 100: 1294-1299
        • Pompon RH
        • Smith AN
        • Baylor C
        • Kendall D.
        Exploring associations between a biological marker of chronic stress and reported depression and anxiety in people with aphasia.
        J Speech Lang Hear Res. 2019; 62: 4119-4130
        • Crosson B
        • Moore AB
        • Gopinath K
        • et al.
        Role of the right and left hemispheres in recovery of function during treatment of intention in aphasia.
        J Cogn Neurosci. 2005; 17: 392-406
        • Benjamin ML
        • Towler S
        • Garcia A
        • et al.
        A behavioral manipulation engages right frontal cortex during aphasia therapy.
        Neurorehabil Neural Repair. 2014; 28: 545-553
        • Bright FAS
        • Kayes NM
        • Worrall L
        • McPherson KM.
        A conceptual review of engagement in healthcare and rehabilitation.
        Disabil Rehabil. 2015; 37: 643-654
        • Williams MW
        • Rapport LJ
        • Hanks RA
        • Parker HA.
        Engagement in rehabilitation therapy and functional outcomes among individuals with acquired brain injuries.
        Disabil Rehabil. 2021; 43: 33-41
        • Brown JA
        • Knollman-Porter K
        • Hux K
        • Wallace SE
        • Deville C.
        Effect of digital highlighting on reading comprehension given text-to-speech technology for people with aphasia.
        Aphasiology. 2021; 35: 200-221
        • Cherney LR
        • Kaye RC
        • Lee JB
        • van Vuuren S.
        Impact of personal relevance on acquisition and generalization of script training for aphasia: a preliminary analysis.
        Am J Speech Lang Pathol. 2015; 24: S913-S922
        • Kiran S
        • Thompson CK.
        Neuroplasticity of language networks in aphasia: advances, updates, and future challenges.
        Front Neurol. 2019; 10: 295
        • Kleim JA
        • Jones TA.
        Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage.
        J Speech Lang Hear Res. 2008; 51: S225-S239
        • Kagan A.
        Supported conversation for adults with aphasia: methods and resources for training conversation partners.
        Aphasiology. 1998; 12: 816-830
        • Fillingham JK
        • Hodgson C
        • Sage K
        • Lambon Ralph MA
        The application of errorless learning to aphasic disorders: A review of theory and practice.
        Neuropsychol Rehabil. 2003; 13: 337-363
        • Middleton EL
        • Schwartz MF.
        Errorless learning in cognitive rehabilitation: a critical review.
        Neuropsychol Rehabil. 2012; 22: 138-168
        • Brookshire RH.
        Effects of task difficulty on sentence comprehension performance of aphasic subjects.
        J Commun Disord. 1976; 9: 167-173
        • Dignam J
        • Copland D
        • Rawlings A
        • O'Brien K
        • Burfein P
        • Rodriguez AD.
        The relationship between novel word learning and anomia treatment success in adults with chronic aphasia.
        Neuropsychologia. 2016; 81: 186-197
        • Vallila-Rohter S.
        Considering learning ability in language rehabilitation plans.
        Perspectives of the ASHA Special Interest Groups. 2017; 2: 23-30
        • Boyle M
        • Gordon J
        • Harnish S
        • et al.
        Evaluating cognitive-linguistic approaches to interventions for aphasia within the Rehabilitation Treatment Specification System (RTSS).
        Arch Phys Med Rehabil. 2021; (Nov 23. [Epub ahead of print])
        • Cherney LR
        • DeDe G
        • Hoover EL
        • Murray L
        • Obermeyer J
        • Pompon RH
        Applying functional communication treatment approaches for aphasia to the Rehabilitation Treatment Specification System (RTSS).
        Arch Phys Med Rehabil. 2021 Nov 3; ([Epub ahead of print])
        • Davis GA
        • Wilcox MJ.
        Adult aphasia rehabilitation: applied pragmatics.
        College Hill Press, San Diego1985
        • Basilakos A
        • Hula W
        • Johnson L
        • Kiran S
        • Walker G
        • Fridriksson J.
        Defining the neurobiological mechanisms of action in aphasia therapies: applying the RTSS framework to research and practice in aphasia.
        Ann Phys Rehabil Med. 2021 Nov 5; ([Epub ahead of print])