- •New application of chest wall vibration with concurrent aerobic training in chronic obstructive pulmonary disease (COPD).
- •Functional capacity may improve in patients with COPD after chest wall vibration.
- •Chest wall vibration does not relieve dyspnea in patients with COPD.
To investigate the effects of continuous chest wall vibration with concurrent aerobic training in addition to a 4-week pulmonary rehabilitation program on dyspnea and functional exercise capacity in patients with chronic obstructive pulmonary disease (COPD).
Randomized, single-blind, placebo-controlled trial.
The Cardiopulmonary Rehabilitation Unit of a tertiary referral subacute rehabilitation center.
A sample of 146 consecutive patients with COPD (Global Initiative for Chronic Obstructive Lung Disease II-III-IV) were assessed for eligibility. The final sample of 40 patients (N=40) was randomized into 3 groups (intervention, sham intervention, control).
All groups carried out 5 sessions per week for 4 weeks of standard pulmonary rehabilitation treatment. The 2 daily 30-minute sessions included aerobic training and resistance training or airway clearance techniques. The intervention group performed the aerobic training with the addition of continuous chest wall vibration applied during cycling, whereas the sham intervention group received continuous chest wall vibration as a placebo during cycling.
Main Outcome Measures
Six-minute walk distance (6MWD) and Barthel Index based on dyspnea (BID).
A total of 36 participants completed the study (69±7 years; forced expiratory volume in 1 second percentage of predicted, 40.15%±15.97%). Intention to treat analysis showed no significant differences between groups for 6MWD and BID. However, the increase in 6MWD was a clinically important difference in the intervention group (42.57±43.87m, P=.003), with a moderate effect size (d=0.58).
Continuous chest wall vibration with concurrent aerobic training in addition to a standard pulmonary rehabilitation program might improve functional exercise capacity compared with usual care, but there were no effects on dyspnea, respiratory muscle function, or quality of life in patients with COPD.
List of abbreviations:BID (Barthel Index based on dyspnea), BODE (body mass index, airflow obstruction, dyspnea, and exercise capacity), CG (control group), COPD (chronic obstructive pulmonary disease), FEV1 (forced expiratory volume in 1 second), FVC (forced vital capacity), ITT (intention-to-treat), MCID (minimal clinically important difference), MEP (maximal expiratory pressure), MIP (maximal inspiratory pressure), 6MWD (6-minute walk distance), SGRQ (St George's Respiratory Questionnaire)
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Published online: March 26, 2021
Accepted: March 12, 2021
Received: February 7, 2021
Presented as an abstract to the European Respiratory Society (ERS), September 6–9, 2020, virtual, in session “Respiratory viruses in the ‘pre COVID-19 era’ (Eur Respir J 2020;56[Suppl 64]:1259).
Clinical Trial Registration No.: NCT03644888.
© 2021 The American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.