Advertisement
REVIEW ARTICLE (META-ANALYSIS)| Volume 102, ISSUE 11, P2201-2218, November 2021

Region-specific Exercises vs General Exercises in the Management of Spinal and Peripheral Musculoskeletal Disorders: A Systematic Review With Meta-analyses of Randomized Controlled Trials

Published:March 05, 2021DOI:https://doi.org/10.1016/j.apmr.2021.01.093

      Abstract

      Objective

      To compare the efficacy of region-specific exercises to general exercises approaches for adults with spinal or peripheral musculoskeletal disorders (MSKDs).

      Data Sources

      Electronic searches were conducted up to April 2020 in Medline, Embase, Cochrane Central Register of Controlled Trials, and Cumulative Index to Nursing and Allied Health.

      Study Selection

      Randomized control trials (RCTs) on the efficacy of region-specific exercises compared to general exercises approaches for adults with various MSKDs.

      Data Extraction

      Mean differences and standardized mean differences were calculated using random-effects inverse variance modeling. Eighteen RCTs (n=1719) were included. Cohorts were composed of participants with chronic neck (n=313) or low back disorders (n=1096) and knee osteoarthritis (OA) (n=310).

      Data Synthesis

      Based on low-quality evidence in the short-term and very low-quality in the mid- and long-term, there were no statistically significant differences between region-specific and general exercises in terms of pain and disability reductions for adults with spinal disorders or knee OA. Secondary analyses for pain reduction in the short-term for neck or low back disorders did not report any statistically significant differences according to very low- to low-quality of evidence.

      Conclusions

      The difference in treatment effect remains uncertain between region-specific and general exercises approaches. Based on very low- to low-quality evidence, there appear to have no differences between both types of exercise approaches for pain reduction or disability for adults with spinal disorders. Future trials may change the current conclusions. More evidence is needed for region-specific exercises compared to general exercises for other peripheral MSKDs including knee OA.

      Keywords

      List of abbreviations:

      CI (confidence interval), GRADE (Grading of Recommendations, Assessment, Development, and Evaluations), LBP (low back pain), MCE (motor control exercise), MD (mean difference), MSKD (musculoskeletal disorder), NRS (Numeric Rating Scale), OA (osteoarthritis), RCT (randomized controlled trial), SF-36 (Short Form-36 Health Survey), SMD (standardized mean difference), VAS (visual analog scale)
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Archives of Physical Medicine and Rehabilitation
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

      1. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.
        Lancet. 2018; 392: 1789-1858
        • Woolf AD
        • Pfleger B.
        Burden of major musculoskeletal conditions.
        Bull World Health Organ. 2003; 81: 646-656
        • Gaskin DJ
        • Richard P.
        The economic costs of pain in the United States.
        J Pain. 2012; 13: 715-724
        • Lin I
        • Wiles L
        • Waller R
        • et al.
        What does best practice care for musculoskeletal pain look like? Eleven consistent recommendations from high-quality clinical practice guidelines: systematic review.
        Br J Sports Med. 2020; 54: 79-86
        • Hayden JA
        • van Tulder MW
        • Malmivaara A
        • Koes BW.
        Exercise therapy for treatment of non-specific low back pain.
        Cochrane Database Syst Rev. 2005; 3CD000335
        • van Middelkoop M
        • Rubinstein SM
        • Verhagen AP
        • Ostelo RW
        • Koes BW
        • van Tulder MW.
        Exercise therapy for chronic nonspecific low-back pain.
        Best Pract Res Clin Rheumatol. 2010; 24: 193-204
        • Andersen LL
        • Kjaer M
        • Sogaard K
        • Hansen L
        • Kryger AI
        • Sjogaard G.
        Effect of two contrasting types of physical exercise on chronic neck muscle pain.
        Arthritis Rheum. 2008; 59: 84-91
        • Babatunde OO
        • Jordan JL
        • Van der Windt DA
        • Hill JC
        • Foster NE
        • Protheroe J.
        Effective treatment options for musculoskeletal pain in primary care: a systematic overview of current evidence.
        PLoS One. 2017; 12e0178621
        • Buchbinder R
        • van Tulder M
        • Oberg B
        • et al.
        Low back pain: a call for action.
        Lancet. 2018; 391: 2384-2388
        • Smith BE
        • Hendrick P
        • Bateman M
        • et al.
        Musculoskeletal pain and exercise-challenging existing paradigms and introducing new.
        Br J Sports Med. 2019; 53: 907-912
        • Koumantakis GA
        • Watson PJ
        • Oldham JA.
        Supplementation of general endurance exercise with stabilisation training versus general exercise only. Physiological and functional outcomes of a randomised controlled trial of patients with recurrent low back pain.
        Clin Biomech (Bristol, Avon). 2005; 20: 474-482
        • Lima LV
        • Abner TSS
        • Sluka KA.
        Does exercise increase or decrease pain? Central mechanisms underlying these two phenomena.
        J Physiol. 2017; 595: 4141-4150
        • Oesch P
        • Kool J
        • Hagen KB
        • Bachmann S.
        Effectiveness of exercise on work disability in patients with non-acute non-specific low back pain: systematic review and meta-analysis of randomised controlled trials.
        J Rehabil Med. 2010; 42: 193-205
        • Geneen LJ
        • Moore RA
        • Clarke C
        • Martin D
        • Colvin LA
        • Smith BH.
        Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews.
        Cochrane Database Syst Rev. 2017; 4CD011279
        • Owen PJ
        • Miller CT
        • Mundell NL
        • et al.
        Which specific modes of exercise training are most effective for treating low back pain? Network meta-analysis.
        Br J Sports Med. 2020; 54: 1279-1287
        • Hall A
        • Copsey B
        • Richmond H
        • et al.
        Effectiveness of tai chi for chronic musculoskeletal pain conditions: updated systematic review and meta-analysis.
        Phys Ther. 2017; 97: 227-238
        • Lam OT
        • Strenger DM
        • Chan-Fee M
        • Pham PT
        • Preuss RA
        • Robbins SM.
        Effectiveness of the McKenzie Method of Mechanical Diagnosis and Therapy for treating low back pain: literature review with meta-analysis.
        J Orthop Sports Phys Ther. 2018; 48: 476-490
        • Saragiotto BT
        • Maher CG
        • Yamato TP
        • et al.
        Motor control exercise for chronic non-specific low-back pain.
        Cochrane Database Syst Rev. 2016; 1CD012004
        • Patel G
        • Walsh N
        • Gooberman-Hill R.
        Managing osteoarthritis in primary care: exploring healthcare professionals’ views on a multiple-joint intervention designed to facilitate self-management.
        Musculoskeletal Care. 2014; 12: 199-209
        • Shire AR
        • Staehr TAB
        • Overby JB
        • Bastholm Dahl M
        • Sandell Jacobsen J
        • Hoyrup Christiansen D
        Specific or general exercise strategy for subacromial impingement syndrome-does it matter? A systematic literature review and meta analysis.
        BMC Musculoskelet Disord. 2017; 18: 158
        • Higgins JPT
        • Sterne JAC
        • Savovic J
        • et al.
        A revised tool for assessing risk of bias in randomized trials.
        Cochrane Database Syst Rev. 2016; 10: 29-31
        • Guyatt GH
        • Oxman AD
        • Kunz R
        • et al.
        GRADE guidelines: 7. Rating the quality of evidence–inconsistency.
        J Clin Epidemiol. 2011; 64: 1294-1302
        • Cohen J.
        Statistical power analysis for the bahavioral sciences.
        Routledge, Abingdon, United Kingdom1988
        • Guyatt GH
        • Oxman AD
        • Vist GE
        • et al.
        GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.
        BMJ. 2008; 336: 924-926
        • Guyatt GH
        • Oxman AD
        • Sultan S
        • et al.
        GRADE guidelines: 9. Rating up the quality of evidence.
        J Clin Epidemiol. 2011; 64: 1311-1316
        • Guyatt GH
        • Oxman AD
        • Kunz R
        • et al.
        GRADE guidelines: 8. Rating the quality of evidence–indirectness.
        J Clin Epidemiol. 2011; 64: 1303-1310
        • Guyatt GH
        • Oxman AD
        • Montori V
        • et al.
        GRADE guidelines: 5. Rating the quality of evidence–publication bias.
        J Clin Epidemiol. 2011; 64: 1277-1282
        • Guyatt GH
        • Oxman AD
        • Vist G
        • et al.
        GRADE guidelines: 4. Rating the quality of evidence–study limitations (risk of bias).
        J Clin Epidemiol. 2011; 64: 407-415
        • Balshem H
        • Helfand M
        • Schunemann HJ
        • et al.
        GRADE guidelines: 3. Rating the quality of evidence.
        J Clin Epidemiol. 2011; 64: 401-406
        • Guyatt GH
        • Oxman AD
        • Kunz R
        • et al.
        GRADE guidelines 6. Rating the quality of evidence–imprecision.
        J Clin Epidemiol. 2011; 64: 1283-1293
        • Aboagye E
        • Karlsson ML
        • Hagberg J
        • Jensen I.
        Cost-effectiveness of early interventions for non-specific low back pain: a randomized controlled study investigating medical yoga, exercise therapy and self-care advice.
        J Rehabil Med. 2015; 47: 167-173
        • Bramberg EB
        • Bergstrom G
        • Jensen I
        • Hagberg J
        • Kwak L.
        Effects of yoga, strength training and advice on back pain: a randomized controlled trial.
        BMC Musculoskelet Disord. 2017; 18: 132
        • Andersen LL
        • Andersen CH
        • Skotte JH
        • et al.
        High-intensity strength training improves function of chronically painful muscles: case-control and RCT studies.
        Biomed Res Int. 2014; 2014187324
        • Brooks C
        • Kennedy S
        • Marshall PW.
        Specific trunk and general exercise elicit similar changes in anticipatory postural adjustments in patients with chronic low back pain: a randomized controlled trial.
        Spine (Phila Pa 1976). 2012; 37: E1543-E1550
        • Demirel A
        • Oz M
        • Ozel YA
        • Cetin H
        • Ulger O.
        Stabilization exercise versus yoga exercise in non-specific low back pain: pain, disability, quality of life, performance: a randomized controlled trial.
        Complement Ther Clin Pract. 2019; 35: 102-108
        • Ferreira ML
        • Ferreira PH
        • Latimer J
        • et al.
        Comparison of general exercise, motor control exercise and spinal manipulative therapy for chronic low back pain: a randomized trial.
        Pain. 2007; 131: 31-37
        • Hurley DA
        • Tully MA
        • Lonsdale C
        • et al.
        Supervised walking in comparison with fitness training for chronic back pain in physiotherapy: results of the SWIFT single-blinded randomized controlled trial (ISRCTN17592092).
        Pain. 2015; 156: 131-147
        • Kofotolis N
        • Kellis E
        • Vlachopoulos SP
        • Gouitas I
        • Theodorakis Y.
        Effects of Pilates and trunk strengthening exercises on health-related quality of life in women with chronic low back pain.
        J Back Musculoskelet Rehabil. 2016; 29: 649-659
        • Kuntz AB
        • Chopp-Hurley JN
        • Brenneman EC
        • et al.
        Efficacy of a biomechanically-based yoga exercise program in knee osteoarthritis: a randomized controlled trial.
        PLoS One. 2018; 13e0195653
        • Lauche R
        • Stumpe C
        • Fehr J
        • et al.
        The effects of tai chi and neck exercises in the treatment of chronic nonspecific neck pain: a randomized controlled trial.
        J Pain. 2016; 17: 1013-1027
        • Messier SP
        • Thompson CD
        • Ettinger Jr., WH
        Effects of long-term aerobic or weight training regimens on gait in an older, osteoarthritic population.
        J Appl Biomech. 1997; 13: 205-225
        • Neyaz O
        • Sumila L
        • Nanda S
        • Wadhwa S.
        Effectiveness of hatha yoga versus conventional therapeutic exercises for chronic nonspecific low-back pain.
        J Altern Complement Med. 2019; 25: 938-945
        • Rasmussen-Barr E
        • Ang B
        • Arvidsson I
        • Nilsson-Wikmar L.
        Graded exercise for recurrent low-back pain: a randomized, controlled trial with 6-, 12-, and 36-month follow-ups.
        Spine (Phila Pa 1976). 2009; 34: 221-228
        • Saeterbakken AH
        • Nordengen S
        • Andersen V
        • Fimland MS.
        Nordic walking and specific strength training for neck- and shoulder pain in office workers: a pilot-study.
        Eur J Phys Rehabil Med. 2017; 53: 928-935
        • Saper RB
        • Lemaster C
        • Delitto A
        • et al.
        Yoga, physical therapy, or education for chronic low back pain: a randomized noninferiority trial.
        Ann Intern Med. 2017; 167: 85-94
        • Sherman KJ
        • Cherkin DC
        • Erro J
        • Miglioretti DL
        • Deyo RA.
        Comparing yoga, exercise, and a self-care book for chronic low back pain: a randomized, controlled trial.
        Ann Intern Med. 2005; 143 (849-18)
        • Shnayderman I
        • Katz-Leurer M.
        An aerobic walking programme versus muscle strengthening programme for chronic low back pain: a randomized controlled trial.
        Clin Rehabil. 2013; 27: 207-214
        • von Trott P
        • Wiedemann AM
        • Ludtke R
        • Reishauer A
        • Willich SN
        • Witt CM.
        Qigong and exercise therapy for elderly patients with chronic neck pain (QIBANE): a randomized controlled study.
        J Pain. 2009; 10: 501-508
        • Zou L
        • Zhang Y
        • Liu Y
        • et al.
        The effects of tai chi chuan versus core stability training on lower-limb neuromuscular function in aging individuals with non-specific chronic lower back pain.
        Medicina (Kaunas). 2019; 55: 60
        • Ettinger Jr, WH
        • Burns R
        • Messier SP
        • et al.
        A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial (FAST).
        JAMA. 1997; 277: 25-31
        • Booth J
        • Moseley GL
        • Schiltenwolf M
        • Cashin A
        • Davies M
        • Hubscher M.
        Exercise for chronic musculoskeletal pain: a biopsychosocial approach.
        Musculoskeletal Care. 2017; 15: 413-421
        • Steiger F
        • Wirth B
        • de Bruin ED
        • Mannion AF.
        Is a positive clinical outcome after exercise therapy for chronic non-specific low back pain contingent upon a corresponding improvement in the targeted aspect(s) of performance? A systematic review.
        Eur Spine J. 2012; 21: 575-598
        • Harber VJ
        • Sutton JR.
        Endorphins and exercise.
        Sports Med. 1984; 1: 154-171
        • Naugle KM
        • Fillingim RB
        • Riley 3rd, JL
        A meta-analytic review of the hypoalgesic effects of exercise.
        J Pain. 2012; 13: 1139-1150
        • Leonard JH
        • Paungmali A
        • Sitilertpisan P
        • Pirunsan U
        • Uthaikhup S.
        Changes in transversus abdominis muscle thickness after lumbo-pelvic core stabilization training among chronic low back pain individuals.
        Clin Ter. 2015; 166: e312-e316
        • Hodges PW
        • Richardson CA.
        Inefficient muscular stabilization of the lumbar spine associated with low back pain. A motor control evaluation of transversus abdominis.
        Spine (Phila Pa 1976). 1996; 21: 2640-2650
        • O'Keeffe M
        • Hayes A
        • McCreesh K
        • Purtill H
        • O'Sullivan K
        Are group-based and individual physiotherapy exercise programmes equally effective for musculoskeletal conditions? A systematic review and meta-analysis.
        Br J Sports Med. 2017; 51: 126-132
        • Bennell KL
        • Hinman RS.
        A review of the clinical evidence for exercise in osteoarthritis of the hip and knee.
        J Sci Med Sport. 2011; 14: 4-9
        • Ferreira PH
        • Ferreira ML
        • Maher CG
        • Refshauge KM
        • Latimer J
        • Adams RD.
        The therapeutic alliance between clinicians and patients predicts outcome in chronic low back pain.
        Phys Ther. 2013; 93: 470-478
        • Kraemer WJ
        • Ratamess NA.
        Fundamentals of resistance training: progression and exercise prescription.
        Med Sci Sports Exerc. 2004; 36: 674-688
        • Gross A
        • Kay TM
        • Paquin JP
        • et al.
        Exercises for mechanical neck disorders.
        Cochrane Database Syst Rev. 2015; 1CD004250
        • Gross AR
        • Paquin JP
        • Dupont G
        • et al.
        Exercises for mechanical neck disorders: a Cochrane review update.
        Man Ther. 2016; 24: 25-45