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Review Article (Meta-Analysis)| Volume 102, ISSUE 11, P2219-2230, November 2021

Effect of Therapeutic Ultrasound for Neck Pain: A Systematic Review and Meta-Analysis

  • Wanyi Qing
    Affiliations
    Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China

    Key Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, PR China
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  • Xian Shi
    Affiliations
    School of Medicine, Guilin Medical University, Guilin, Guangxi, PR China
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  • Qing Zhang
    Affiliations
    Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China

    Key Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, PR China
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  • Lihong Peng
    Affiliations
    Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China

    Key Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, PR China
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  • Chengqi He
    Affiliations
    Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China

    Key Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, PR China
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  • Quan Wei
    Correspondence
    Corresponding author Quan Wei, MD, PhD, Rehabilitation Medicine Center and Institute of Rehabilitation Medicine and Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, Sichuan, PR China.
    Affiliations
    Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China

    Key Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, PR China
    Search for articles by this author
Published:March 12, 2021DOI:https://doi.org/10.1016/j.apmr.2021.02.009

      Abstract

      Objective

      To evaluate the effects and safety of therapeutic ultrasound in patients with neck pain.

      Data Sources

      The PubMed, EMBASE, CENTRAL, and Physiotherapy Evidence databases were searched for articles published before December 1, 2020.

      Study Selection

      Randomized controlled trials that compared the effects of therapeutic ultrasound on neck pain were included in this review. The included studies compared therapeutic ultrasound plus other treatments with the other treatments alone or compared therapeutic ultrasound with sham or no treatment. Outcome measures involved the effects on pain, disability, and quality of life. Other treatments included all nonultrasonic therapies (eg, various exercises, massage, electrotherapy).

      Data Extraction

      Data on the study population, therapeutic ultrasound intervention, combined intervention, outcome measures, and follow-up were extracted.

      Data Synthesis

      Twelve randomized controlled trials (705 patients) fulfilled the inclusion criteria. Seven studies compared therapeutic ultrasound plus other treatments vs the other treatments alone (449 patients). Therapeutic ultrasound yielded additional benefits for pain, but there was high heterogeneity and we could not draw a clear conclusion. Ultrasound did not have a better effect on disability or quality of life when it was combined with other treatments. Five studies compared therapeutic ultrasound with sham or no treatment (256 patients), and the pooled data showed that therapeutic ultrasound significantly reduced pain intensity. No adverse events of therapeutic ultrasound were reported in the included studies.

      Conclusions

      Therapeutic ultrasound may reduce the intensity of pain more than sham or no treatment, and it is a safe treatment. Whether therapeutic ultrasound in combination with other conventional treatments produced additional benefits on pain intensity, disability, or quality of life is not clear. The randomized trials included in this review had different levels of quality and high heterogeneity. A large trial using a valid methodology is warranted.

      Keywords

      List of abbreviations:

      CI (confidence interval), GRADE (Grading of Recommendations, Assessment, Development and Evaluation), MPS (myofascial pain syndrome), MTrP (myofascial trigger point), NDI (neck disability index), NHP (Nottingham health profile), NRS (numerical rating scale), PEDro (Physiotherapy Evidence Database), QoL (quality of life), RCT (randomized controlled trial), SMD (standardized mean difference), VAS (visual analog scale)
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