Abstract
Objective
To assess the therapeutic effect of platelet-rich plasma (PRP) for moderate-to-severe
carpal tunnel syndrome (CTS).
Design
A prospective, randomized, double-blinded, controlled trial (1-year follow-up).
Setting
Outpatient of local medical center settings.
Participants
Patients (N=26) who were diagnosed with bilateral moderate-to-severe CTS (total 52
wrists) were included. For each patient, one wrist was randomized into either the
PRP or control group and the contralateral wrist of the same patient was allocated
to another group.
Twenty-four patients were included in the final data analysis.
Interventions
The wrists in the PRP group received a single ultrasound-guided dose of PRP injection
(3.5mL), and the control group received a single ultrasound-guided injection with
normal saline (3.5mL).
Main Outcome Measures
The Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) scores were used as the primary
outcome. Secondary outcomes encompassed the cross-sectional area of the median nerve
and electrophysiological study. Assessments were conducted prior to injection and
1, 3, 6, and 12 months postinjection.
Results
Compared to the control group, the PRP group exhibited significant improvements in
BCTQ severity scores at all time points, BCTQ functional scores at the sixth month,
and cross-sectional area at the 12th month postinjection (P<.0125).
Conclusions
A single dose of ultrasound-guided perineural PRP injection can provide therapeutic
effect for 1 year postinjection.
Keywords
List of abbreviations:
BCTQ (Boston Carpal Tunnel Syndrome Questionnaire), CSA (cross-sectional area), CTS (carpal tunnel syndrome), DML (distal motor latency), FSS (functional status scale), MCID (minimal clinically important difference), NS (normal saline), PRP (platelet-rich plasma), SNCV (sensory nerve conduction velocity), SSCT (subsynovial connective tissue), SSS (symptom severity scale)To read this article in full you will need to make a payment
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Article Info
Publication History
Published online: February 03, 2021
Footnotes
Supported by the Ministry of Science and Technology, Taiwan , Republic of China (grant no. MOST 106-2314-B-016-009 ).
Disclosures: none.
Identification
Copyright
© 2021 by the American Congress of Rehabilitation Medicine