Abstract
Objective
To determine the effect of aerobic exercise on maximal and submaximal cardiopulmonary
responses and predictors of change in individuals with Parkinson's disease (PD).
Design
Single-center, parallel-group, rater-blind study.
Setting
Research laboratory.
Participants
Individuals with mild to moderate PD (N=100).
Intervention
Participants were enrolled in a trial evaluating the effect of cycling on PD and randomized
to either voluntary exercise (VE), forced exercise (FE), or a no exercise control
group. The exercise groups were time and intensity matched and exercised 3×/wk for
8 weeks on a stationary cycle.
Main Outcome Measures
Cardiopulmonary responses were collected via gas analysis during a maximal graded
exercise test at baseline and post intervention.
Results
Exercise attendance was 97% and 93% for the FE and VE group, respectively. Average
exercise heart rate reserve was 67%±11% for FE and 70%±10% for VE. No significant
difference was present for change in peak oxygen consumption (VO2peak) post intervention, even though the FE group had a 5% increase in VO2peak. Both the FE and VE groups had significantly higher percentage oxygen consumption
per unit time (o2) at ventilator threshold (VT) than the control group compared with baseline values
(P=.04). Mean O2 at VT was 5% (95% CI, 0.1%-11%) higher in the FE group (P=.04) and 7% (2%, 12%) higher in VE group compared with controls. A stepwise linear
regression model revealed that lower age, higher exercise cadence, and lower baseline
VO2peak were most predictive of improved VO2peak. The overall model was found to be significant (P<.01).
Conclusions
Peak and submaximal cardiopulmonary function may improve after aerobic exercise in
individuals with PD. Lower age, higher exercise cadence, and lower baseline VO2peak were most predictive of improved VO2peak in this exercise cohort. The improvements observed in aerobic capacity were gained
after a relatively short aerobic cycling intervention.
Keywords
List of abbreviations:
ADL (activities of daily living), CYCLE (Cyclical Lower Extremity Exercise), EOT (end of treatment), FE (forced exercise), GXT (graded exercise test), MET (metabolic equivalent task), MDS-UPDRS III (Movement Disorders Society Unified Parkinson’s Disease Rating Scale Motor III), PD (Parkinson's disease), VE (voluntary exercise), V˙O2 (volume of oxygen consumption per unit time), VO2peak (peak oxygen consumption), VT (ventilator threshold)To read this article in full you will need to make a payment
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Article Info
Publication History
Published online: January 13, 2021
Footnotes
Supported by the National Institutes of Health (grant no. R01NS673717 ).
Clinical Trial Registration No.: NCT01636297.
Disclosures: J.L.A. has authored intellectual property related to the control of the forced-exercise cycle. The other authors have nothing to disclose.
Identification
Copyright
© 2021 by the American Congress of Rehabilitation Medicine
