To examine if 8 weeks of high-intensity interval training (HIIT) in addition to standard care would increase and maintain peak oxygen uptake (Vo2peak) more than standard care alone in patients with stroke.
This was a single-blind, multicenter, parallel group, randomized controlled trial.
Specialized rehabilitation units at 3 Norwegian hospitals.
Participants (N=70), 3 months to 5 years after first-ever stroke, were randomly assigned to the intervention group (n=36) or the control group (n=34); 42% were women, mean age was 57.6±9.3 years, mean time post stroke was 26.4±14.5 months.
The intervention was 8 weeks: 3 times a week with HIIT treadmill training with work periods of 4 × 4 minutes at 85%-95% of peak heart rate interspersed with 3 minutes of active recovery at 50%-70% of peak heart rate. The control group received standard care according to national guidelines.
The primary outcome, analyzed by intention-to-treat, was Vo2peak measured as liters per minute 12 months after inclusion. Secondary outcome measures were blood pressure and blood profile.
Mean baseline Vo2peak was 2.63±1.08 L·min−1 vs 2.87±0.71 L·min−1, while at 12 months Vo2peak was 2.70±1.00 L·min−1 vs 2.67±0.76 L·min−1 (P=.068) in the intervention and control groups, respectively. There was a significant and greater improvement in the intervention group compared with the control group at 12 months in 3 of 6 secondary outcomes from the peak test but no significant differences for blood pressure or blood profile.
The HIIT intervention, which was well-tolerated in this sample of well-functioning survivors of stroke, was not superior to standard care in improving and maintaining Vo2peak at the 12-month follow-up. However, secondary results from the peak test showed a significant improvement from before to immediately after the intervention.
List of abbreviations:HIIT (high-intensity interval training), PT (physical therapist), Vo2peak (peak oxygen uptake)
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Archives of Physical Medicine and Rehabilitation
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.Stroke. 2011; 42: 227-276
- Secondary stroke prevention.Lancet Neurol. 2014; 13: 178-194
- Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy.Lancet. 2012; 380: 219-229
- Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013.BMJ. 2016; 354: i3857
- Physical activity and exercise recommendations for stroke survivors: a statement for healthcare professionals from the American Heart Association/American Stroke Association.Stroke. 2014; 45: 2532-2553
- Physical fitness training for stroke patients.Cochrane Database Syst Rev. 2016; 3: CD003316
- Oxygen uptake during functional activities after stroke-reliability and validity of a portable ergospirometry system.PLoS One. 2017; 12e0186894
- Peak aerobic capacity predicts prognosis in patients with coronary heart disease.Am Heart J. 2008; 156: 292-300
- A simple nonexercise model of cardiorespiratory fitness predicts long-term mortality.Med Sci Sports Exerc. 2014; 46: 1159-1165
- High-intensity interval training after stroke: an opportunity to promote functional recovery, cardiovascular health, and neuroplasticity.Neurorehabil Neural Repair. 2018; 32: 543-556
- High intensity interval training for maximizing health outcomes.Prog Cardiovasc Dis. 2017; 60: 67-77
- High intensity aerobic interval exercise is superior to moderate intensity exercise for increasing aerobic capacity in patients with coronary artery disease.European J Cardiovasc Prev Rehabil. 2004; 11: 216-222
- Aerobic high-intensity intervals improve VO2max more than moderate training.Med sci sports exerc. 2007; 39: 665-671
- High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis.Br J Sports Med. 2014; 48: 1227-1234
- Effect of high aerobic intensity interval treadmill walking in people with chronic stroke: a pilot study with one year follow-up.Top Stroke Rehabil. 2012; 19: 353-360
- High-intensity aerobic interval training for patients 3-9 months after stroke. A feasibility study.Physiother Res Int. 2013; 19: 129-139
- High-intensity interval training and moderate-intensity continuous training in ambulatory chronic stroke: feasibility study.Phys Ther. 2016; 96: 1533-1544
- Validity and reliability of the Cortex MetaMax3B portable metabolic system.J Sports Sci. 2010; 28: 733-742
- Exercise standards for testing and training: a scientific statement from the American Heart Association.Circulation. 2013; 128: 873-934
- Blood pressure measurement anno 2016.Am J Hypertens. 2017; 30: 453-463
- Evaluation of a body-worn sensor system to measure physical activity in older people with impaired function.Phys Ther. 2011; 91: 277-285
- Different ways to estimate treatment effects in randomised controlled trials.Contemp Clin Trials Commun. 2018; 10: 80-85
- High-intensity interval training in patients with heart failure with reduced ejection fraction.Circulation. 2017; 135: 839-849
- Aerobic interval training versus continuous moderate exercise after coronary artery bypass surgery: a randomized study of cardiovascular effects and quality of life.Am Heart J. 2009; 158: 1031-1037
- Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study.Circulation. 2008; 118: 346-354
- Chronic stroke survivors benefit from high-intensity aerobic treadmill exercise: a randomized control trial.Neurorehabil neural repair. 2012; 26: 85-95
- Higher treadmill training intensity to address functional aerobic impairment after stroke.J Stroke Cerebrovasc Dis. 2015; 24: 2539-2546
- Cardio-respiratory reference data in 4631 healthy men and women 20-90 years: the HUNT 3 fitness study.PLoS One. 2014; 9e113884
- Effect of 24 sessions of high-intensity aerobic interval training carried out at either high or moderate frequency, a randomized trial.PLoS One. 2014; 9e88375
Published online: March 04, 2020
Supported by the Liaison Committee for education, research, and innovation in Central Norway.
Clinical Trial Registration No.: NCT02550015.
© 2020 by the American Congress of Rehabilitation Medicine