Original research| Volume 101, ISSUE 4, P587-591, April 2020

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Minimal Clinically Important Differences in Functional Independence After a Knowledge Translation Intervention in Stroke Rehabilitation

Published:November 15, 2019DOI:



      To examine the odds of persons with stroke achieving minimal clinically important difference (MCID) in functional independence during inpatient rehabilitation relative to cognitive impairment (CI) severity, site, and rehabilitation teams’ exposure to a Cognitive Orientation to daily Occupational Performance (CO-OP) knowledge translation (KT) intervention.


      A pre-post observational study was conducted using data from a centralized referral system. Our research team implemented a CO-OP KT intervention as part of a larger study aimed at training teams to use the CO-OP approach.


      Five inpatient rehabilitation units.


      Cases extracted from a centralized referral system from the 5 participating units.


      Not applicable.

      Main Outcome Measures

      The FIM instrument data from 12 months preintervention and 6 months postintervention were analyzed. A logistic regression was performed to determine the odds ratios (ORs) for achieving MCID based on sample cohort (historical control not exposed to CO-OP KT vs post-CO-OP KT intervention), controlling for site and severity of CI.


      A model that considered the intervention, admission score, CI severity, and site was the best fit for the cases analyzed. Those with severe CI were less likely to achieve FIM total MCID compared to those with no CI (P=<.001; OR=.18; 95% confidence interval, .09-.39). Taking site and CI into account, cases post CO-OP KT intervention were significantly more likely to achieve MCID on FIM motor (P=.048; OR=1.4; 95% confidence interval, 1.00-1.98) than historical controls.


      The CO-OP KT intervention is associated with increased odds of achieving MCID in the FIM motor subscale in inpatient stroke rehabilitation.


      List of abbreviations:

      CI (cognitive impairment), CO-OP (Cognitive Orientation to daily Occupational Performance), E-stroke (E-Stroke Rehabilitation Referral System), KT (knowledge translation), MCID (minimal clinically important difference), OR (odds ratio)
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