Abstract
Objective
To compare the effects of high vs moderate loads of intradialytic resistance training
(RT) on body composition, sarcopenia prevalence, functional capacity, inflammatory
markers, and quality of life (QoL) in individuals on hemodialysis.
Design
A pilot randomized clinical trial.
Setting
Two hemodialysis centers.
Participants
Individuals on hemodialysis (N=80; 51% men, aged 30-75y) in treatment for at least
3 months, adequately dialyzed (Kt/V≥1.2, where K is dialyzer clearance in mL/min,
t is time, and V is volume of water) with vascular access via arteriovenous fistula.
Interventions
The 12 weeks of intradialytic RT was performed 3 times per week. The training groups
were: high-load intradialytic group (HLG, 8-10 repetitions), moderate-load intradialytic
group (MLG, 16-18 repetitions), and control group (CG, stretching exercise). The total
training volume was equalized among training groups.
Main Outcome Measures
Lean leg mass was assessed by a dual-energy x-ray absorptiometry; functional capacity
was assessed by Short Physical Performance Battery and Timed Up and Go test; and QoL
was assessed by Kidney Disease QoL Instrument, inflammatory markers, and sarcopenia.
Results
After the training period, the HLG increased lean leg mass compared with the CG. The
HLG also displayed improvements in the pain and physical function domains. The skeletal
muscle index and functional capacity increased in both RT protocols. The prevalence
of sarcopenia was reduced 14.3% and 25% in the MLG and HLG, respectively, while there
was an increase of 10% in the CG. No differences were observed in cytokines after
intervention.
Conclusions
High-load intradialytic RT was associated with gains in lean leg mass and QoL while
functional capacity, appendicular muscle mass, and sarcopenia status were improved
regardless of the RT load.
Keywords
List of abbreviations:
CG (control group), CKD (chronic kidney disease), DXA (dual-energy x-ray absorptiometry), ES (effect size), HLG (high-load group), IL-6 (interleukin 6), IL-10 (interleukin 10), MLG (moderate-load group), QoL (quality of life), RM (repetition maximum), RT (resistance training), TNF-α (tumor necrosis factor alpha)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: July 03, 2019
Footnotes
Supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior with the scholarship awarded to Lorena Cristina Curado Lopes.
Clinical Trial Registration No.: RBR-5n6sg.
Disclosures: none.
Identification
Copyright
© 2019 by the American Congress of Rehabilitation Medicine
