Highlights
- •People with progressive multiple sclerosis (MS) consume 2.81 times more energy during mobility tasks.
- •Accumulation of oxygen cost and fatigue suggest deconditioning in persons with MS.
- •Oxygen cost of walking is a significant predictor of fatigue in progressive MS.
Abstract
Objective
To compare the oxygen costs of mobility tasks between individuals with progressive
multiple sclerosis (MS) using walking aids and matched controls and to determine whether
oxygen cost predicted fatigue.
Design
Cross-sectional descriptive.
Setting
A rehabilitation research laboratory.
Participants
A total of 14 adults with progressive MS (mean age ± SD [y], 54.07±8.46) using walking
aids and 8 age- and sex-matched controls without MS (N=22).
Interventions
Participants performed 5 mobility tasks (rolling in bed, lying to sitting, sitting
to standing, walking, climbing steps) wearing a portable metabolic cart.
Main Outcome Measures
Oxygen consumption (o2) during mobility tasks, maximal o2 during graded maximal exercise test, perceived exertion, and task-induced fatigue
were measured on a visual analog scale before and after mobility tasks.
Results
People with progressive MS had significantly higher oxygen cost in all tasks compared
to controls (P<.05): climbing steps (3.60 times more in MS), rolling in bed (3.53), walking (3.10),
lying to sitting (2.50), and sitting to standing (1.82). There was a strong, positive
correlation between task-induced fatigue and oxygen cost of walking, (ρ [13]=0.626,
P=.022).
Conclusions
People with progressive MS used 2.81 times more energy on average for mobility tasks
compared to controls. People with progressive MS experienced accumulation of oxygen
cost, fatigue, and exertion when repeating tasks and higher oxygen cost during walking
was related to greater perception of fatigue. Our findings suggest that rehabilitation
interventions that increase endurance during functional tasks could help reduce fatigue
in people with progressive MS who use walking aids.
Keywords
List of abbreviations:
GXT (graded exercise testing), MS (multiple sclerosis), VAS (visual analog scale), V˙o2 (oxygen consumption per unit time), V˙o2max (maximal oxygen consumption), RPE (rating of perceived exertion)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: April 23, 2019
Footnotes
Supported by the Program of Experimental Medicine Graduate Scholarship (to A.D.); the Translational and Personalized Medicine Initiative/NL SUPPORT Educational Funding (to A.D.); Research and Development Corporation (grant no. 5404.1699.104) (to M.P.); Canada Research Chairs Program (grant no. 230457) (to M.P.); and the Canada Foundation for Innovation (grant no. 33621) (to M.P.).
Disclosures: none.
Identification
Copyright
© 2019 by the American Congress of Rehabilitation Medicine
