Original research| Volume 100, ISSUE 2, P230-238, February 2019

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Maximum Walking Speed at Discharge Could Be a Prognostic Factor for Vascular Events in Patients With Mild Stroke: A Cohort Study



      To identify the prognostic value of physical activity-related factors as well as known vascular risk factors for vascular events in mild ischemic stroke (MIS).


      Single-center prospective cohort study.


      University hospital.


      Consecutive patients (N=255) (175 men, median age 70.0y) with acute ischemic stroke and transient ischemic attack (TIA) with modified Rankin scale scores ranging from 0 to 2 were enrolled in this study.


      Not applicable.

      Main Outcome Measures

      Enrolled patients were followed up for composite vascular events as primary outcomes up to 3 years postdischarge. Primary outcomes included stroke and cardiovascular death, hospitalization due to stroke or TIA recurrence, cardiovascular disease, and peripheral artery disease. During hospitalization, known vascular risk factors such as previous history of vascular events, stroke subtype, white matter lesions, and ankle-brachial index were assessed. Moreover, at the time of discharge, physical activity-related factors such as maximum walking speed (MWS), handgrip strength, knee extensor isometric muscle strength, anxiety, and depression were assessed as potential predictors.


      The Kaplan-Meier estimates of cumulative risk of composite vascular events at 1, 2, and 3 years were 9.6%, 14.4%, and 15.2%, respectively. After multivariate analysis, cerebral white matter lesions of periventricular hyperintensity (PVH) (grade=3; hazard ratio: 2.904; 95% confidence interval: 1.160 to 7.266; P=.023) and MWS (<1.45m/s; hazard ratio: 2.232; 95% confidence interval: 1.010 to 4.933; P=.047) were identified as significant independent predictors of composite vascular events.


      The results of this study indicate that MWS could be an independent prognostic factor for composite vascular events in MIS.


      List of Abbreviations:

      BMI (body mass index), DBP (diastolic blood pressure), DWMH (deep white matter hyperintensity), HbA1c (hemoglobin A1c), HDL-C (high-density lipoprotein cholesterol), LDL-C (low-density lipoprotein cholesterol), MIS (mild ischemic stroke), mRS (modified Rankin Scale), MWS (maximum walking speed), PA (physical activity), PVH (periventricular hyperintensity), SBP (systolic blood pressure), TG (triglycerides), TIA (transient ischemic attack)
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