To evaluate the effect of quadriceps functional electrical stimulation (FES)-cycling on exertional oxygen uptake (o2) compared with placebo FES-cycling in patients with chronic obstructive pulmonary disease (COPD).
A randomized, single-blind, placebo-controlled crossover trial.
Pulmonary rehabilitation department.
Consecutive patients (N=23) with COPD Global Initiative for Chronic Obstructive Lung Disease stage 2, 3, or 4 (mean forced expiratory volume during the first second, 1.4±0.4L [50.3% predicted]) who had recently begun a respiratory rehabilitation program.
Two consecutive 30-minute sessions were carried out at a constant load with active and placebo FES-cycling.
Main Outcome Measures
The primary outcome was mean o2 during the 30-minute exercise session. The secondary outcomes were respiratory gas exchange and hemodynamic parameters averaged over the 30-minute endurance session. Lactate values, dyspnea, and perceived muscle fatigue were evaluated at the end of the sessions.
FES-cycling increased the physiological response more than the placebo, with a greater o2 achieved of 36.6mL/min (95% confidence interval [CI], 8.9–64.3mL/min) (P=.01). There was also a greater increase in lactate after FES-cycling (+1.5mmol/L [95% CI, .05–2.9mmol/L]; P=.01). FES-cycling did not change dyspnea or muscle fatigue compared with the placebo condition.
FES-cycling effectively increased exercise intensity in patients with COPD. Further studies should evaluate longer-term FES-cycling rehabilitation programs.
List of abbreviations:CI (confidence interval), COPD (chronic obstructive pulmonary disease), FES (functional electrical stimulation), TENS (transcutaneous electrical nerve stimulation), V˙co2 (carbon dioxide production), V˙e (minute ventilation), V˙o2 (oxygen uptake), Vo2peak (peak oxygen uptake)
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Published online: March 07, 2018
Supported by grants from the ADIR Association. The funder has not had any direct influence on the design of the study, the analysis of data, the data collection, drafting of the manuscript, or the decision to publish.
Clinical Trial Registration No.: NCT02594722 (ClinicalTrials.gov).
© 2018 by the American Congress of Rehabilitation Medicine