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Effects of Timing and Intensity of Neurorehabilitation on Functional Outcome After Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Published:February 08, 2018DOI:https://doi.org/10.1016/j.apmr.2018.01.013

      Abstract

      Objective

      To systematically review evidence on the effects of timing and intensity of neurorehabilitation on the functional recovery of patients with moderate to severe traumatic brain injury (TBI) and aggregate the available evidence using meta-analytic methods.

      Data Sources

      PubMed, Embase, PsycINFO, and Cochrane Database.

      Study Selection

      Electronic databases were searched for prospective controlled clinical trials assessing the effect of timing or intensity of multidisciplinary neurorehabilitation programs on functional outcome of patients with moderate or severe TBI. A total of 5961 unique records were screened for relevance, of which 58 full-text articles were assessed for eligibility by 2 independent authors. Eleven articles were included for systematic review and meta-analysis.

      Data Extraction

      Two independent authors performed data extraction and risk of bias analysis using the Cochrane Collaboration tool. Discrepancies between authors were resolved by consensus.

      Data Synthesis

      Systematic review of a total of 6 randomized controlled trials, 1 quasi-randomized trial, and 4 controlled trials revealed consistent evidence for a beneficial effect of early onset neurorehabilitation in the trauma center and intensive neurorehabilitation in the rehabilitation facility on functional outcome compared with usual care. Meta-analytic quantification revealed a large-sized positive effect for early onset rehabilitation programs (d=1.02; P<.001; 95% confidence interval [CI], 0.56–1.47) and a medium-sized positive effect for intensive neurorehabilitation programs (d=.67; P<.001; 95% CI, .38–.97) compared with usual care. These effects were replicated based solely on studies with a low overall risk of bias.

      Conclusions

      The available evidence indicates that early onset neurorehabilitation in the trauma center and more intensive neurorehabilitation in the rehabilitation facility promote functional recovery of patients with moderate to severe TBI compared with usual care. These findings support the integration of early onset and more intensive neurorehabilitation in the chain of care for patients with TBI.

      Keywords

      List of abbreviations:

      GCS (Glasgow Coma Scale), GOSE (Glasgow Outcome Scale-Extended), RCT (randomized controlled trial), TBI (traumatic brain injury)
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      References

        • Feigin V.L.
        • Theadom A.
        • Barker-Collo S.
        • et al.
        Incidence of traumatic brain injury in New Zealand: a population-based study.
        Lancet Neurol. 2013; 12: 53-64
        • Walker W.C.
        • Pickett T.C.
        Motor impairment after severe traumatic brain injury: a longitudinal multicenter study.
        J Rehabil Res Dev. 2007; 44: 975-982
        • Königs M.
        • Engenhorst P.J.
        • Oosterlaan J.
        Intelligence after traumatic brain injury: meta-analysis of outcomes and prognosis.
        Eur J Neurol. 2016; 23: 21-29
        • Finch E.
        • Copley A.
        • Cornwell P.
        • Kelly C.
        Systematic review of behavioral interventions targeting social communication difficulties after traumatic brain injury.
        Arch Phys Med Rehabil. 2016; 97: 1352-1365
        • Scaratti C.
        • Leonardi M.
        • Sattin D.
        • Schiavolin S.
        • Willems M.
        • Raggi A.
        Work-related difficulties in patients with traumatic brain injury: a systematic review on predictors and associated factors.
        Disabil Rehabil. 2017; 39: 847-855
        • Polinder S.
        • Haagsma J.A.
        • van Klaveren D.
        • Steyerberg E.W.
        • van Beeck E.F.
        Health-related quality of life after TBI: a systematic review of study design, instruments, measurement properties, and outcome.
        Popul Health Metr. 2015; 13: 4
        • Hylin M.J.
        • Kerr A.L.
        • Holden R.
        Understanding the mechanisms of recovery and/or compensation following injury.
        Neural Plast. 2017; : 2017
        • Kleim J.A.
        • Jones T.A.
        Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage.
        J Speech Lang Hear Res. 2008; 51: S225-S239
        • Turner-Stokes L.
        • Pick A.
        • Nair A.
        • Disler P.B.
        • Wade D.T.
        Multi-disciplinary rehabilitation for acquired brain injury in adults of working age.
        Cochrane Database Syst Rev. 2015; : CD004170
        • Turner-Stokes L.
        Evidence for the effectiveness of multi-disciplinary rehabilitation following acquired brain injury: a synthesis of two systematic approaches.
        J Rehabil Med. 2008; 40: 691-701
        • Thompson J.
        • Majumdar J.
        Acute neurorehabilitation versus treatment as usual.
        Br J Neurosurg. 2013; 27: 24-29
        • Eicher V.
        • Murphy M.P.
        • Murphy T.F.
        • Malec J.F.
        Progress assessed with the Mayo-Portland Adaptability Inventory in 604 participants in 4 types of post-inpatient rehabilitation brain injury programs.
        Arch Phys Med Rehabil. 2012; 93: 100-107
        • Shamseer L.
        • Moher D.
        • Clarke M.
        • et al.
        Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation.
        BMJ. 2015; 349: g7647
        • Anderson V.A.
        • Northam E.
        • Wrennall J.
        Developmental neuropsychology: a clinical approach.
        Taylor & Francis, New York2014
        • Higgins J.P.
        • Altman D.G.
        • Gøtzsche P.C.
        • et al.
        The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials.
        BMJ. 2011; 343: d5928
        • Borenstein M.
        Comprehensive meta-analysis.
        Biostat, Englewood, NJ2005
        • Cohen J.
        Statistical power analysis for the behavioral science.
        Erlbaum, Hillsdale1988
        • Rosenthal R.
        Writing meta-analytic reviews.
        Psychol Bull. 1995; 118: 183-192
        • Egger M.
        • Davey Smith G.
        • Schneider M.
        • Minder C.
        Bias in meta-analysis detected by a simple, graphical test.
        BMJ. 1997; 315: 629-634
        • Mackay L.E.
        • Bernstein B.A.
        • Chapman P.E.
        • Morgan A.S.
        • Milazzo L.S.
        Early intervention in severe head injury: long-term benefits of a formalized program.
        Arch Phys Med Rehabil. 1992; 73: 635-641
        • Langhorn L.
        • Holdgaard D.
        • Worning L.
        • Sørensen J.C.
        • Pedersen P.U.
        Testing a reality orientation program in patients with traumatic brain injury in a neurointensive care unit.
        J Neurosci Nurs. 2015; 47: E2-E10
        • Andelic N.
        • Bautz-Holter E.
        • Ronning P.
        • et al.
        Does an early onset and continuous chain of rehabilitation improve the long-term functional outcome of patients with severe traumatic brain injury?.
        J Neurotrauma. 2012; 29: 66-74
        • Abbasi M.
        • Mohammadi E.
        • Sheaykh Rezayi A.
        Effect of a regular family visiting program as an affective, auditory, and tactile stimulation on the consciousness level of comatose patients with a head injury.
        Japan J Nurs Sci. 2009; 6: 21-26
        • Megha M.
        • Harpreet S.
        • Nayeem Z.
        Effect of frequency of multimodal coma stimulation on the consciousness levels of traumatic brain injury comatose patients.
        Brain Inj. 2013; 27: 570-577
        • Moattari M.
        • Shirazi F.
        • Sharifi N.
        • Zareh N.
        Effects of a sensory stimulation by nurses and families on level of cognitive function, and basic cognitive sensory recovery of comatose patients with severe.
        Trauma Mon. 2016; 21: e23531
        • Shiel A.
        • Burn J.P.
        • Henry D.
        • et al.
        The effects of increased rehabilitation therapy after brain injury: results of a prospective controlled trial.
        Clin Rehabil. 2001; 15: 501-514
        • Zhu X.L.
        • Poon W.S.
        • Chan C.C.
        • Chan S.S.
        Does intensive rehabilitation improve the functional outcome of patients with traumatic brain injury (TBI)? A randomized controlled trial.
        Brain Inj. 2007; 21: 681-690
        • Sarajuuri J.M.
        • Kaipio M.L.
        • Koskinen S.K.
        • Niemelä M.R.
        • Servo A.R.
        • Vilkki J.S.
        Outcome of a comprehensive neurorehabilitation program for patients with traumatic brain injury.
        Arch Phys Med Rehabil. 2005; 86: 2296-2302
        • Canning C.
        • Shepherd R.
        • Carr J.
        • Alison J.
        • Allana L.
        A randomized controlled trial of the effects of intensive sit-to-stand training after recent traumatic brain injury on sit-to-stand performance.
        Clin Rehabil. 2003; 17
        • Cicerone K.D.
        • Mott T.
        • Azulay J.
        • Friel J.C.
        Community integration and satisfaction with functioning after intensive cognitive rehabilitation for traumatic brain injury.
        Arch Phys Med Rehabil. 2004; 85: 943-950
        • Forsyth R.
        • Basu A.
        The promotion of recovery through rehabilitation after acquired brain injury in children.
        Dev Med Child Neurol. 2015; 57: 16-22
        • Cooke E.V.
        • Mares K.
        • Clark A.
        • Tallis R.C.
        • Pomeroy V.M.
        The effects of increased dose of exercise-based therapies to enhance motor recovery after stroke: a systematic review and meta-analysis.
        BMC Med. 2010; 8: 60
        • Turner-Stokes L.
        • Disler P.B.
        • Nair A.
        • Wade D.T.
        Multi-disciplinary rehabilitation for acquired brain injury in adults of working age.
        Cochrane Database Syst Rev. 2005; : CD004170
        • Crespi C.M.
        Improved designs for cluster randomized trials.
        Annu Rev Public Health. 2016; 37: 1-16
        • Rietbergen C.
        • Moerbeek M.
        The design of cluster randomized crossover trials.
        J Educ Behav Stat. 2011; 36: 472-490
        • Hicks R.
        • Giacino J.
        • Harrison-Felix C.
        • Manley G.
        • Valadka A.
        • Wilde E.A.
        Progress in developing common data elements for traumatic brain injury research: version two – the end of the beginning.
        J Neurotrauma. 2013; 30: 1852-1861