Donders and Pendery
1
examined the ability of the Patient Health Questionnaire-9 (PHQ-9) to screen for
symptoms of depression after broad-spectrum traumatic brain injury (TBI). In 137 patients
with TBI, PHQ-9 scores≥10 had a sensitivity of 91.7 and a specificity of 60.2 for
predicting the diagnosis of major depression. The correlation coefficients between
the scores of the PHQ-9 and Minnesota Multiphasic Personality Inventory-2-Restructured
Form (MMPI-2-RF) demoralization and low positive emotions scales were .64 and .48,
respectively. I have some concerns about this study.To read this article in full you will need to make a payment
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References
- Clinical utility of the Patient Health Questionnaire-9 in the assessment of major depression after broad-spectrum traumatic brain injury.Arch Phys Med Rehabil. 2017; 98: 2514-2519
- Events per variable (EPV) and the relative performance of different strategies for estimating the out-of-sample validity of logistic regression models.Stat Methods Med Res. 2017; 26: 796-808
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© 2017 by the American Congress of Rehabilitation Medicine
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- The Authors RespondArchives of Physical Medicine and RehabilitationVol. 99Issue 5
- PreviewWe have mixed feelings about this feedback. On the one hand, we acknowledge that the number of events per variable for some of the logistic regression analyses, particularly the one to predict a final diagnosis of major depression on the basis of demographic and injury variables, was suboptimal. This was because of the relatively low number of participants (N=24, 17%) with such a diagnosis. We could have addressed this by limiting the number of predictors in the model but decided against this because (1) they had been selected a priori for theoretical reasons, and (2) the participant-to-variable ratio in the model was acceptable.
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