Advertisement

Lower Quadriceps Rate of Force Development Is Associated With Worsening Physical Function in Adults With or at Risk for Knee Osteoarthritis: 36-Month Follow-Up Data From the Osteoarthritis Initiative

Published:February 04, 2018DOI:https://doi.org/10.1016/j.apmr.2017.12.027

      Abstract

      Objective

      To determine the association between quadriceps rate of force development (RFD) and decline in self-reported physical function and objective measures of physical performance.

      Design

      Longitudinal cohort study.

      Setting

      Community-based sample from 4 urban areas.

      Participants

      Osteoarthritis Initiative participants with or at risk for knee osteoarthritis, who had no history of knee/hip replacement, knee injury, or rheumatoid arthritis (N=2630).

      Interventions

      Not applicable.

      Main Outcome Measures

      Quadriceps RFD (N/s) was measured during isometric strength testing. Worsening physical function was defined as the minimal clinically important difference for worsening self-reported Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function subscale score, 20-m walk time, and repeated chair stand time over 36 months.

      Results

      Compared with the slowest tertile of RFD, the fastest tertile had a lower risk for worsening of WOMAC physical function subscale score at 36-month follow-up, with an odds ratio (OR) of .68 (95% confidence interval [CI], .51–.92) after adjustment for age, sex, body mass index, depression, history of chronic diseases, and knee pain. In women, in comparison with the slowest tertile of RFD, the fastest tertile had a lower risk for worsening of WOMAC physical function subscale score at 36-month follow-up, with an adjusted OR of .57 (95% CI, .38–.86). This decreased risk did not reach statistical significance in men (OR, 0.81; 95% CI, 0.52–1.27). No statistically significant associations were detected between baseline RFD and walk or chair stand times.

      Conclusions

      Our results indicate that higher RFD is associated with decreased risk for worsening self-reported physical function but not with decreased risk for worsening of physical performance.

      Keywords

      List of abbreviations:

      BMI (body mass index), CI (confidence interval), MCID (minimal clinically important difference), OA (osteoarthritis), OAI (Osteoarthritis Initiative), OR (odds ratio), RFD (rate of force development), RM (repetition maximum), WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index)
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Archives of Physical Medicine and Rehabilitation
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Guccione A.A.
        • Felson D.T.
        • Anderson J.J.
        • et al.
        The effects of specific medical conditions on the functional limitations of elders in the Framingham Study.
        Am J Public Health. 1994; 84: 351-358
        • van Dijk G.M.
        • Dekker J.
        • Veenhof C.
        • van den Ende C.H.
        • Carpa Study Group
        Course of functional status and pain in osteoarthritis of the hip or knee: a systematic review of the literature.
        Arthritis Rheum. 2006; 55: 779-785
        • van Leeuwen D.M.
        • Peeters G.M.
        • de Ruiter C.J.
        • et al.
        Effects of self-reported osteoarthritis on physical performance: a longitudinal study with a 10-year follow-up.
        Aging Clin Exp Res. 2013; 25: 561-569
        • Segal N.A.
        • Zimmerman M.B.
        • Brubaker M.
        • Torner J.C.
        Obesity and knee osteoarthritis are not associated with impaired quadriceps specific strength in adults.
        PM R. 2011; 3: 314-323
        • Conroy M.B.
        • Kwoh C.K.
        • Krishnan E.
        • et al.
        Muscle strength, mass, and quality in older men and women with knee osteoarthritis.
        Arthritis Care Res (Hoboken). 2012; 64: 15-21
        • Segal N.A.
        • Torner J.C.
        • Felson D.
        • et al.
        Effect of thigh strength on incident radiographic and symptomatic knee osteoarthritis in a longitudinal cohort.
        Arthritis Rheum. 2009; 61: 1210-1217
        • Oiestad B.E.
        • Juhl C.B.
        • Eitzen I.
        • Thorlund J.B.
        Knee extensor muscle weakness is a risk factor for development of knee osteoarthritis. A systematic review and meta-analysis.
        Osteoarthritis Cartilage. 2015; 23: 171-177
        • Segal N.A.
        • Glass N.A.
        • Torner J.
        • et al.
        Quadriceps weakness predicts risk for knee joint space narrowing in women in the MOST cohort.
        Osteoarthritis Cartilage. 2010; 18: 769-775
        • Glass N.A.
        • Torner J.C.
        • Frey Law L.A.
        • et al.
        The relationship between quadriceps muscle weakness and worsening of knee pain in the MOST cohort: a 5-year longitudinal study.
        Osteoarthritis Cartilage. 2013; 21: 1154-1159
        • Culvenor A.G.
        • Wirth W.
        • Ruhdorfer A.
        • Eckstein F.
        Thigh muscle strength predicts knee replacement risk independent of radiographic disease and pain in women: data from the Osteoarthritis Initiative.
        Arthritis Rheumatol. 2016; 68: 1145-1155
        • Ruhdorfer A.
        • Wirth W.
        • Eckstein F.
        Relationship between isometric thigh muscle strength and minimum clinically important differences in knee function in osteoarthritis: data from the osteoarthritis initiative.
        Arthritis Care Res (Hoboken). 2015; 67: 509-518
        • Pisters M.F.
        • Veenhof C.
        • van Dijk G.M.
        • Heymans M.W.
        • Twisk J.W.
        • Dekker J.
        The course of limitations in activities over 5 years in patients with knee and hip osteoarthritis with moderate functional limitations: risk factors for future functional decline.
        Osteoarthritis Cartilage. 2012; 20: 503-510
        • Aagaard P.
        • Simonsen E.B.
        • Andersen J.L.
        • Magnusson P.
        • Dyhre-Poulsen P.
        Increased rate of force development and neural drive of human skeletal muscle following resistance training.
        J Appl Physiol (1985). 2002; 93: 1318-1326
        • de Ruiter C.J.
        • Kooistra R.D.
        • Paalman M.I.
        • de Haan A.
        Initial phase of maximal voluntary and electrically stimulated knee extension torque development at different knee angles.
        J Appl Physiol (1985). 2004; 97: 1693-1701
        • Mayson D.J.
        • Kiely D.K.
        • LaRose S.I.
        • Bean J.F.
        Leg strength or velocity of movement: which is more influential on the balance of mobility limited elders?.
        Am J Phys Med Rehabil. 2008; 87: 969-976
        • Bean J.F.
        • Kiely D.K.
        • LaRose S.
        • Leveille S.G.
        Which impairments are most associated with high mobility performance in older adults? Implications for a rehabilitation prescription.
        Arch Phys Med Rehabil. 2008; 89: 2278-2284
        • Sayers S.P.
        • Guralnik J.M.
        • Thombs L.A.
        • Fielding R.A.
        Effect of leg muscle contraction velocity on functional performance in older men and women.
        J Am Geriatr Soc. 2005; 53: 467-471
        • Tillin N.A.
        • Pain M.T.
        • Folland J.
        Explosive force production during isometric squats correlates with athletic performance in rugby union players.
        J Sports Sci. 2013; 31: 66-76
        • Ward R.E.
        • Beauchamp M.K.
        • Latham N.K.
        • et al.
        Neuromuscular impairments contributing to persistently poor and declining lower-extremity mobility among older adults: new findings informing geriatric rehabilitation.
        Arch Phys Med Rehabil. 2016; 97: 1316-1322
        • Rannou F.
        • Poiraudeau S.
        Non-pharmacological approaches for the treatment of osteoarthritis.
        Best Pract Res Clin Rheumatol. 2010; 24: 93-106
        • Bartholdy C.
        • Juhl C.
        • Christensen R.
        • Lund H.
        • Zhang W.
        • Henriksen M.
        The role of muscle strengthening in exercise therapy for knee osteoarthritis: a systematic review and meta-regression analysis of randomized trials.
        Semin Arthritis Rheum. 2017; 47: 9-21
        • Lord J.P.
        • Aitkens S.G.
        • McCrory M.A.
        • Bernauer E.M.
        Isometric and isokinetic measurement of hamstring and quadriceps strength.
        Arch Phys Med Rehabil. 1992; 73: 324-330
        • Kawamori N.
        • Rossi S.J.
        • Justice B.D.
        • et al.
        Peak force and rate of force development during isometric and dynamic mid-thigh clean pulls performed at various intensities.
        J Strength Cond Res. 2006; 20: 483-491
        • Bohannon R.W.
        Test-retest reliability of the five-repetition sit-to-stand test: a systematic review of the literature involving adults.
        J Strength Cond Res. 2011; 25: 3205-3207
        • Bellamy N.
        • Bensen W.G.
        • Ford P.M.
        • Huang S.H.
        • Lang J.Y.
        Double-blind randomized controlled trial of flurbiprofen-SR (ANSAID-SR) and diclofenac sodium-SR (Voltaren-SR) in the treatment of osteoarthritis.
        Clin Invest Med. 1992; 15: 427-433
        • Perera S.
        • Mody S.H.
        • Woodman R.C.
        • Studenski S.A.
        Meaningful change and responsiveness in common physical performance measures in older adults.
        J Am Geriatr Soc. 2006; 54: 743-749
        • Tubach F.
        • Ravaud P.
        • Baron G.
        • et al.
        Evaluation of clinically relevant changes in patient reported outcomes in knee and hip osteoarthritis: the minimal clinically important improvement.
        Ann Rheum Dis. 2005; 64: 29-33
        • Tilson J.K.
        • Sullivan K.J.
        • Cen S.Y.
        • et al.
        Meaningful gait speed improvement during the first 60 days poststroke: minimal clinically important difference.
        Phys Ther. 2010; 90: 196-208
        • Curb J.D.
        • Ceria-Ulep C.D.
        • Rodriguez B.L.
        • et al.
        Performance-based measures of physical function for high-function populations.
        J Am Geriatr Soc. 2006; 54: 737-742
        • Wise B.L.
        • Niu J.
        • Felson D.T.
        • et al.
        Functional impairment is a risk factor for knee replacement in the Multicenter Osteoarthritis Study.
        Clin Orthop Relat Res. 2015; 473: 2505-2513
        • Michl G.L.
        • Katz J.N.
        • Losina E.
        Risk and risk perception of knee osteoarthritis in the US: a population-based study.
        Osteoarthritis Cartilage. 2016; 24: 593-596
        • Zheng H.
        • Chen C.
        Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies.
        BMJ Open. 2015; 5: e007568
        • Kouzis A.C.
        • Eaton W.W.
        Emotional disability days: prevalence and predictors.
        Am J Public Health. 1994; 84: 1304-1307
        • McKnight-Eily L.R.
        • Elam-Evans L.D.
        • Strine T.W.
        • et al.
        Activity limitation, chronic disease, and comorbid serious psychological distress in U.S. adults–BRFSS 2007.
        Int J Public Health. 2009; : 111-119
        • Irwin M.
        • Artin K.H.
        • Oxman M.N.
        Screening for depression in the older adult: criterion validity of the 10-item Center for Epidemiological Studies Depression Scale (CES-D).
        Arch Intern Med. 1999; 159: 1701-1704
        • Charlson M.
        • Szatrowski T.P.
        • Peterson J.
        • Gold J.
        Validation of a combined comorbidity index.
        J Clin Epidemiol. 1994; 47: 1245-1251
        • Maffiuletti N.A.
        • Bizzini M.
        • Widler K.
        • Munzinger U.
        Asymmetry in quadriceps rate of force development as a functional outcome measure in TKA.
        Clin Orthop Relat Res. 2010; 468: 191-198
        • Winters J.D.
        • Rudolph K.S.
        Quadriceps rate of force development affects gait and function in people with knee osteoarthritis.
        Eur J Appl Physiol. 2014; 114: 273-284
        • Batsis J.A.
        • Zbehlik A.J.
        • Barre L.K.
        • Bynum J.P.
        • Pidgeon D.
        • Bartels S.J.
        Impact of obesity on disability, function, and physical activity: data from the Osteoarthritis Initiative.
        Scand J Rheumatol. 2015; 44: 495-502
        • Johnson V.L.
        • Hunter D.J.
        The epidemiology of osteoarthritis.
        Best Pract Res Clin Rheumatol. 2014; 28: 5-15
        • Schmitz A.
        • Silder A.
        • Heiderscheit B.
        • Mahoney J.
        • Thelen D.G.
        Differences in lower-extremity muscular activation during walking between healthy older and young adults.
        J Electromyogr Kinesiol. 2009; 19: 1085-1091
        • Larsen A.H.
        • Puggaard L.
        • Hamalainen U.
        • Aagaard P.
        Comparison of ground reaction forces and antagonist muscle coactivation during stair walking with ageing.
        J Electromyogr Kinesiol. 2008; 18: 568-580
        • Maffiuletti N.A.
        • Aagaard P.
        • Blazevich A.J.
        • Folland J.
        • Tillin N.
        • Duchateau J.
        Rate of force development: physiological and methodological considerations.
        Eur J Appl Physiol. 2016; 116: 1091-1116
        • Angelozzi M.
        • Madama M.
        • Corsica C.
        • et al.
        Rate of force development as an adjunctive outcome measure for return-to-sport decisions after anterior cruciate ligament reconstruction.
        J Orthop Sports Phys Ther. 2012; 42: 772-780
        • Penailillo L.
        • Blazevich A.
        • Numazawa H.
        • Nosaka K.
        Rate of force development as a measure of muscle damage.
        Scand J Med Sci Sports. 2015; 25: 417-427
        • Vila-Cha C.
        • Falla D.
        • Farina D.
        Motor unit behavior during submaximal contractions following six weeks of either endurance or strength training.
        J Appl Physiol (1985). 2010; 109: 1455-1466
        • Zhang W.
        • Nuki G.
        • Moskowitz R.W.
        • et al.
        OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through January 2009.
        Osteoarthritis Cartilage. 2010; 18: 476-499
        • Skou S.T.
        • Wise B.L.
        • Lewis C.E.
        • et al.
        Muscle strength, physical performance and physical activity as predictors of future knee replacement: a prospective cohort study.
        Osteoarthritis Cartilage. 2016; 24: 1350-1356
        • Spector T.D.
        • Nandra D.
        • Hart D.J.
        • Doyle D.V.
        Is hormone replacement therapy protective for hand and knee osteoarthritis in women?: The Chingford Study.
        Ann Rheum Dis. 1997; 56: 432-434
        • Zhang Y.
        • McAlindon T.E.
        • Hannan M.T.
        • et al.
        Estrogen replacement therapy and worsening of radiographic knee osteoarthritis: the Framingham Study.
        Arthritis Rheum. 1998; 41: 1867-1873
        • Boyan B.D.
        • Hart D.A.
        • Enoka R.M.
        • et al.
        Hormonal modulation of connective tissue homeostasis and sex differences in risk for osteoarthritis of the knee.
        Biol Sex Differ. 2013; 4: 3
        • de Klerk B.M.
        • Schiphof D.
        • Groeneveld F.P.
        • et al.
        No clear association between female hormonal aspects and osteoarthritis of the hand, hip and knee: a systematic review.
        Rheumatology (Oxford). 2009; 48: 1160-1165
        • Boyan B.D.
        • Tosi L.L.
        • Coutts R.D.
        • et al.
        Addressing the gaps: sex differences in osteoarthritis of the knee.
        Biol Sex Differ. 2013; 4: 4
        • Sharma L.
        • Cahue S.
        • Song J.
        • Hayes K.
        • Pai Y.C.
        • Dunlop D.
        Physical functioning over three years in knee osteoarthritis: role of psychosocial, local mechanical, and neuromuscular factors.
        Arthritis Rheum. 2003; 48: 3359-3370