Abstract
Objective
To determine the association between quadriceps rate of force development (RFD) and
decline in self-reported physical function and objective measures of physical performance.
Design
Longitudinal cohort study.
Setting
Community-based sample from 4 urban areas.
Participants
Osteoarthritis Initiative participants with or at risk for knee osteoarthritis, who
had no history of knee/hip replacement, knee injury, or rheumatoid arthritis (N=2630).
Interventions
Not applicable.
Main Outcome Measures
Quadriceps RFD (N/s) was measured during isometric strength testing. Worsening physical
function was defined as the minimal clinically important difference for worsening
self-reported Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
physical function subscale score, 20-m walk time, and repeated chair stand time over
36 months.
Results
Compared with the slowest tertile of RFD, the fastest tertile had a lower risk for
worsening of WOMAC physical function subscale score at 36-month follow-up, with an
odds ratio (OR) of .68 (95% confidence interval [CI], .51–.92) after adjustment for
age, sex, body mass index, depression, history of chronic diseases, and knee pain.
In women, in comparison with the slowest tertile of RFD, the fastest tertile had a
lower risk for worsening of WOMAC physical function subscale score at 36-month follow-up,
with an adjusted OR of .57 (95% CI, .38–.86). This decreased risk did not reach statistical
significance in men (OR, 0.81; 95% CI, 0.52–1.27). No statistically significant associations
were detected between baseline RFD and walk or chair stand times.
Conclusions
Our results indicate that higher RFD is associated with decreased risk for worsening
self-reported physical function but not with decreased risk for worsening of physical
performance.
Keywords
List of abbreviations:
BMI (body mass index), CI (confidence interval), MCID (minimal clinically important difference), OA (osteoarthritis), OAI (Osteoarthritis Initiative), OR (odds ratio), RFD (rate of force development), RM (repetition maximum), WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: February 04, 2018
Footnotes
The Osteoarthritis Initiative (OAI) is a public-private partnership comprised of 5 contracts (nos. N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, and N01-AR-2-2262) funded by the National Institutes of Health, a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners include Merck Research Laboratories; Novartis Pharmaceuticals Corporation, GlaxoSmithKline; and Pfizer. Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health.
This article was prepared using an OAI public use data set and does not necessarily reflect the opinions or views of the OAI investigators, the National Institutes of Health, or the private funding partners.
Clinical Trial Registration No.: NCT00080171.
Disclosures: none.
Identification
Copyright
© 2018 by the American Congress of Rehabilitation Medicine
