Original research| Volume 99, ISSUE 5, P819-825, May 2018

Effects of Classic Progressive Resistance Training Versus Eccentric-Enhanced Resistance Training in People With Multiple Sclerosis

Published:November 27, 2017DOI:



      To compare the effects of classic progressive resistance training (PRT) versus eccentric strength-enhanced training (EST) on the performance of functional tests and different strength manifestations in the lower limb of people with multiple sclerosis (PwMS).


      Experimental trial.


      Strength training program.


      PwMS (N=52; 19 men, 33 women) belonging to MS associations from the Castilla y León, Spain.


      Participants were assigned to 1 of 2 groups: a control group that performed PRT or an experimental group that performed EST. In both groups, the knee extensor muscles were trained for 12 weeks.

      Main Outcome Measures

      Before and after 12 weeks of training, maximal voluntary isometric contraction and 1 repetition maximum (1RM) of the knee extensors were evaluated, as were the Chair Stand Test (CST) and Timed 8-Foot Up and Go (TUG) functional tests.


      No differences were found between the groups in the initial values for different tests. Intragroup comparisons found significant differences in CST (F=69.4; P<.001), TUG (F=40.0; P<.001), and 1RM (F=57.8; P<.001). For intergroup comparisons, EST presented better results than PRT in the CST (EST, 4.7%±2.8%; PRT, 1.9%±2.8%; F=13.1; P=.001) and TUG (EST, −2.9±4.7; PRT, −.41±5.6; F=5.6; P=.022).


      In PwMS, EST leads to improvements in 1RM, TUG, and CST that are similar to those of PRT. However, for patients who participated in this study, the EST seems to promote a better transfer of strength adaptations to the functional tests, which are closer to daily-living activities.


      List of abbreviations:

      CST (Chair Stand Test), EST (eccentric strength-enhanced training), MS (multiple sclerosis), MVIC (maximal voluntary isometric contraction), 1RM (1 repetition maximum), PRT (progressive resistance training), PwMS (patients with multiple sclerosis), TUG (Timed 8-Foot Up and Go)
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