There is a growing interest in individual response differences and exploring potential predictors of these individual responses. The recent study by Layne et al
1was a secondary analysis of data from the Lifestyle Interventions and Independence for Elders study,
- Layne A.S.
- Hsu F.C.
- Blair S.N.
- et al.
Predictors of change in physical function in older adults in response to long-term, structured physical activity: the LIFE study.
Arch Phys Med Rehabil. 2017; 98: 11-24.e3
2and focused on individual differences in response to the physical activity intervention that was implemented. The primary outcomes were physical function (gait speed over 400m) and lower extremity function assessed at baseline and 6, 12, and 24 months. Participants were randomized to an intervention group (n=818) involving a moderate-intensity physical activity program, or a comparator group (n=817) involving monthly workshops covering relevant health information. We have some comments and questions regarding this study.
- Pahor M.
- Guralnik J.M.
- Ambrosius W.T.
- et al.
Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial.
JAMA. 2014; 311: 2387-2396
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- Predictors of change in physical function in older adults in response to long-term, structured physical activity: the LIFE study.Arch Phys Med Rehabil. 2017; 98: 11-24.e3
- Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial.JAMA. 2014; 311: 2387-2396
- True and false interindividual differences in the physiological response to an intervention.Exp Physiol. 2015; 100: 577-588
- Blood pressure status and post-exercise hypotension: an example of a spurious correlation in hypertension research?.J Hum Hypertens. 2010; 24: 585-592
© 2017 by the American Congress of Rehabilitation Medicine