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Review article (meta-analysis)| Volume 99, ISSUE 4, P743-757, April 2018

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Ulnar Nerve Cross-Sectional Area for the Diagnosis of Cubital Tunnel Syndrome: A Meta-Analysis of Ultrasonographic Measurements

  • Ke-Vin Chang
    Correspondence
    Corresponding author Ke-Vin Chang, MD, PhD, Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch and National Taiwan University College of Medicine, Taipei 10845, Taiwan.
    Affiliations
    Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taipei, Taiwan

    Department of Physical and Rehabilitation Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
    Search for articles by this author
  • Wei-Ting Wu
    Affiliations
    Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taipei, Taiwan
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  • Der-Sheng Han
    Affiliations
    Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taipei, Taiwan

    Department of Physical and Rehabilitation Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
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  • Levent Özçakar
    Affiliations
    Department of Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey
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Published:September 06, 2017DOI:https://doi.org/10.1016/j.apmr.2017.08.467

      Abstract

      Objective

      To examine the performance of sonographic cross-sectional area (CSA) measurements in the diagnosis of cubital tunnel syndrome (CuTS).

      Data Sources

      Electronic databases, comprising PubMed and EMBASE, were searched for the pertinent literature before July 1, 2017.

      Study Selection

      Fourteen trials comparing the ulnar nerve CSA measurements between participants with and without CuTS were included.

      Data Extraction

      Study design, participants' demographic characteristics, diagnostic reference of CuTS, and methods of CSA measurement.

      Data Synthesis

      Among different elbow levels, the between-group difference in CSA was the largest at the medial epicondyle (6.0mm2; 95% confidence interval [CI], 4.5–7.4mm2). The pooled mean CSA in participants without CuTS was 5.5mm2 (95% CI, 4.4–6.6mm2) at the arm level, 7.4mm2 (95% CI, 6.7–8.1mm2) at the cubital tunnel inlet, 6.6mm2 (95% CI, 5.9–7.2mm2) at the medial epicondyle, 7.3mm2 (95% CI, 5.6–9.0mm2) at the cubital tunnel outlet, and 5.5mm2 (95% CI, 4.7–6.3mm2) at the forearm level. The sensitivities, specificities, and diagnostic odds ratios pooled from 5 studies, using 10mm2 as the cutoff point, were .85 (95% CI, .78–.90), .91 (95% CI, .86–.94), and 53.96 (95% CI, 14.84–196.14), respectively.

      Conclusions

      The ulnar nerve CSA measured by ultrasound imaging is useful for the diagnosis of CuTS and is most significantly different between patients and participants without CuTS at the medial epicondyle. Because the ulnar nerve CSA in healthy participants, at various locations, rarely exceeds 10mm2, this value can be considered as a cutoff point for diagnosing ulnar nerve entrapment at the elbow region.

      Keywords

      List of abbreviations:

      CI (confidence interval), CSA (cross-sectional area), CuTS (cubital tunnel syndrome), QUADAS (Quality Assessment of Diagnostic Accuracy Studies)
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