Review article (meta-analysis)| Volume 99, ISSUE 2, P383-389.e1, February 2018

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Effectiveness of Exercise Programs in Ankylosing Spondylitis: A Meta-Analysis of Randomized Controlled Trials

Published:August 28, 2017DOI:



      To assess the effectiveness of exercise programs on disease activity and function in ankylosing spondylitis (AS) by a systematic review and meta-analysis of randomized controlled trials (RCTs).

      Data Sources

      Medline via PubMed and Cochrane Library.

      Study Selection

      Reports of RCTs examining the effectiveness of exercise programs for AS published up to May 2017.

      Data Extraction

      Outcomes were evolution of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) after the completion of exercise programs. Modalities of exercise were compared and the use of biologic therapy was reported.

      Data Synthesis

      After screening 190 abstracts, we selected 26 reports for detailed evaluation and finally investigated 8 trials that assessed a home-based exercise program (2/8), swimming (1/8), Pilates training (1/8), or supervised exercises (4/8), for a total of 331 patients with AS. Four trials included patients receiving antitumor necrosis factor therapy. All trials except one showed a decrease in BASDAI and BASFI with exercise. The weighted mean difference was −0.90 (95% confidence interval, −1.52 to −0.27; I2=69%; P=.005) for the BASDAI and −0.72 (95% confidence interval, −1.03 to −0.40; I2=0%; P<.00001) for the BASFI in favor of exercise programs.


      Despite the small number of patients and the heterogeneity of exercise programs in the RCTs included in this meta-analysis, its results support the potential of exercise programs to improve disease activity and body function in AS.


      List of abbreviations:

      AS (ankylosing spondylitis), BASDAI (Bath Ankylosing Spondylitis Disease Activity Index), BASFI (Bath Ankylosing Spondylitis Functional Index), CI (confidence interval), RCT (randomized controlled trial), TNF (tumor necrosis factor), WMD (weighted mean difference)
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