Abstract
Objective
To evaluate the effects of a progressive resistance training (RT) on cardiac autonomic
modulation and on cardiovascular responses to autonomic stress tests in patients with
Parkinson disease (PD).
Design
Randomized clinical trial.
Setting
The Brazil Parkinson Association.
Participants
Patients (N=30) with PD (modified Hoehn & Yahr stages 2–3) were randomly divided into
2 groups: a progressive RT group (PD training [PDT] group) and a control group (PD
control [PDC] group). In addition, a group of paired healthy control (HC) subjects
without PD was evaluated.
Interventions
The PDT group performed 5 resistance exercises, 2 to 4 sets, 12 to 6 repetitions maximum
per set. Individuals in the PDC group maintained their usual lifestyle.
Main Outcome Measures
The PDT and PDC groups were evaluated before and after 12 weeks. The HC group was
evaluated once. Autonomic function was assessed by spectral analysis of heart rate
variability and cardiovascular responses to autonomic stress tests (deep breathing,
Valsalva maneuver, orthostatic stress).
Results
Compared with baseline, the normalized low-frequency component of heart rate variability
decreased significantly after 12 weeks in the PDT group only (PDT: 61±17 normalized
units [nu] vs 47±20nu; PDC: 60±14nu vs 63±10nu; interaction P<.05). A similar result was observed for systolic blood pressure fall during orthostatic
stress that also was reduced only in the PDT group (PDT: −14±11mmHg vs −6±10mmHg;
PDC: −12±10mmHg vs −11±10mmHg; interaction P<.05). In addition, after 12 weeks, these parameters in the PDT group achieved values
similar to those in the HC group.
Conclusions
In patients with PD, progressive RT improved cardiovascular autonomic dysfunction.
Keywords
List of abbreviations:
HC (healthy control), HFR-R (high-frequency component of R-R interval variability), LFR-R (low-frequency component of R-R interval variability), PD (Parkinson disease), PDC (PD control), PDT (PD training), RM (repetition maximum), RT (resistance training)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: July 10, 2017
Footnotes
Supported by the Brazilian Council for the Scientific and Technological Development (CNPQ, process 142017/2012-4 and 304003-2014-0) and the Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES, process 99999.010276/2014-09 and Program with Academic Excellence (PROEX).
Brazilian Clinical Trial Registration Nos.: RBR-5YC53K and U111-1129-0762.
Disclosures: none.
Identification
Copyright
© 2017 by the American Congress of Rehabilitation Medicine
