Abstract
Objective
To investigate the effects of arm-cranking exercise training on plasminogen activator
inhibitor 1 (PAI-1) as a risk factor of deep vein thrombosis, along with general physical
parameters such as muscle strength, aerobic capacity, and hemodynamics, in individuals
with spinal cord injury (SCI) and control subjects.
Design
Longitudinal study.
Setting
Community-based supervised intervention.
Participants
Participants (N=17) comprised individuals with SCI (n=9) who volunteered for this
study, and able-bodied individuals (n=8) matched for age, height, and body mass index
who were assessed at baseline only.
Intervention
The arm-cranking exercise program was performed for 10 weeks with 4 sessions per week.
Sessions consisted of 2 sets of warmup (5min) and arm crank exercises (25min) with
a 10-minute recovery at an intensity of 50% to 70% of heart rate reserve.
Main Outcome Measures
Body mass (BM), waist circumference (WC), aerobic capacity (peak oxygen consumption
[Vo2peak]), PAI-1, blood pressure, glucose metabolism, and lipids.
Results
PAI-1, BM, WC, systolic blood pressure, and triglycerides (TG) decreased, and Vo2peak increased after training (P<.05, respectively). Spearman rank-order analysis revealed that changes in PAI-1 were
related to changes in Vo2peak, BM, WC, TG, and high-density lipoprotein cholesterol. Multiple linear regression
analysis revealed that WC was the most sensitive factor for predicting changes in
PAI-1 (P=.038).
Conclusions
These results suggest that 10 weeks of arm-cranking exercise training for people with
SCI may help to reduce the risk factors of cardiovascular disease. In addition, changes
in abdominal fat may be related to changes in PAI-1 in the SCI population.
Keywords
List of abbreviations:
AB (able-bodied), BM (body mass), CVD (cardiovascular disease), DVT (deep vein thrombosis), HDL-C (high-density lipoprotein cholesterol), HRR (heart rate reserve), PAI-1 (plasminogen activator inhibitor 1), SBP (systolic blood pressure), SCI (spinal cord injury), TG (triglycerides), Vo2peak (peak oxygen uptake), WC (waist circumference)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: March 09, 2017
Footnotes
Supported by the Japan Society for the Promotion of the Science (grant no. 16700497), and in part by a grant of MEXT-Supported Program for the Strategic Research Foundation at Private Universities, 2015-2017 and a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, KAKENHI (grant no.15KO1625).
Disclosures: none.
Identification
Copyright
© 2017 by the American Congress of Rehabilitation Medicine
