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Arm-Cranking Exercise Training Reduces Plasminogen Activator Inhibitor 1 in People With Spinal Cord Injury

  • Masahiro Horiuchi
    Correspondence
    Corresponding author Masahiro Horiuchi, PhD, Kami-yoshida 5597-1, Fuji-yoshida, Yamanashi 4030005, Japan.
    Affiliations
    Division of Human Environmental Science, Mt. Fuji Research Institute, Fuji-yoshida-city, Yamanashi, Japan

    Northern Region of Life Long Sports Center, Hokusho University, Ebetsu-city, Hokkaido, Japan
    Search for articles by this author
  • Koichi Okita
    Affiliations
    Northern Region of Life Long Sports Center, Hokusho University, Ebetsu-city, Hokkaido, Japan

    Department of Sport Education, School of Life Long Sport, Hokusho University, Ebetsu-city, Hokkaido, Japan
    Search for articles by this author
Published:March 09, 2017DOI:https://doi.org/10.1016/j.apmr.2017.02.007

      Abstract

      Objective

      To investigate the effects of arm-cranking exercise training on plasminogen activator inhibitor 1 (PAI-1) as a risk factor of deep vein thrombosis, along with general physical parameters such as muscle strength, aerobic capacity, and hemodynamics, in individuals with spinal cord injury (SCI) and control subjects.

      Design

      Longitudinal study.

      Setting

      Community-based supervised intervention.

      Participants

      Participants (N=17) comprised individuals with SCI (n=9) who volunteered for this study, and able-bodied individuals (n=8) matched for age, height, and body mass index who were assessed at baseline only.

      Intervention

      The arm-cranking exercise program was performed for 10 weeks with 4 sessions per week. Sessions consisted of 2 sets of warmup (5min) and arm crank exercises (25min) with a 10-minute recovery at an intensity of 50% to 70% of heart rate reserve.

      Main Outcome Measures

      Body mass (BM), waist circumference (WC), aerobic capacity (peak oxygen consumption [Vo2peak]), PAI-1, blood pressure, glucose metabolism, and lipids.

      Results

      PAI-1, BM, WC, systolic blood pressure, and triglycerides (TG) decreased, and Vo2peak increased after training (P<.05, respectively). Spearman rank-order analysis revealed that changes in PAI-1 were related to changes in Vo2peak, BM, WC, TG, and high-density lipoprotein cholesterol. Multiple linear regression analysis revealed that WC was the most sensitive factor for predicting changes in PAI-1 (P=.038).

      Conclusions

      These results suggest that 10 weeks of arm-cranking exercise training for people with SCI may help to reduce the risk factors of cardiovascular disease. In addition, changes in abdominal fat may be related to changes in PAI-1 in the SCI population.

      Keywords

      List of abbreviations:

      AB (able-bodied), BM (body mass), CVD (cardiovascular disease), DVT (deep vein thrombosis), HDL-C (high-density lipoprotein cholesterol), HRR (heart rate reserve), PAI-1 (plasminogen activator inhibitor 1), SBP (systolic blood pressure), SCI (spinal cord injury), TG (triglycerides), Vo2peak (peak oxygen uptake), WC (waist circumference)
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