Advertisement
Original research| Volume 97, ISSUE 12, P2027-2033, December 2016

Effects of a Home-Based Upper Limb Training Program in Patients With Multiple Sclerosis: A Randomized Controlled Trial

      Abstract

      Objective

      To evaluate the effects of a home-based upper limb training program on arm function in patients with multiple sclerosis (MS). Additionally, the effects of this program on manual dexterity, handgrip strength, and finger prehension force were analyzed.

      Design

      Randomized, single-blind controlled trial.

      Setting

      Home based.

      Participants

      Patients with a clinical diagnosis of MS acknowledging impaired manual ability (N=37) were randomized into 2 groups.

      Interventions

      Patients in the experimental group were included in a supervised home-based upper limb training program for 8 weeks twice a week. Patients in the control group received information in the form of a leaflet with a schedule of upper limb exercise training.

      Main Outcome Measures

      The primary outcome measure was arm function (motor functioning assessed using the finger tapping test and a functional measure, the Action Research Arm Test). The secondary outcome measures were manual dexterity assessed with the Purdue Pegboard Test and handgrip strength and finger prehension force evaluated with a handgrip and a pinch dynamometer, respectively.

      Results

      After 8 weeks, a significant between-group improvement (P<.05) was found on the Action Research Arm Test bilaterally and the finger tapping test in the most affected upper limb. The secondary outcomes also improved in the most affected limb in the experimental group.

      Conclusions

      An 8-week home-based intervention program focused on upper limbs twice a week improved arm function and physiologic variables with a primary focus on the more affected extremity in patients with MS compared with the control group.

      Keywords

      List of abbreviations:

      MS (multiple sclerosis)
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Archives of Physical Medicine and Rehabilitation
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Confavreux C.
        • Vukusic S.
        • Moreau T.
        • Adeleine P.
        Relapses and progression of disability in multiple sclerosis.
        N Engl J Med. 2000; 343: 1430-1438
        • Trapp B.D.
        • Peterson J.
        • Ransohoff R.M.
        • Rudick R.
        • Mörk S.
        • Bö L.
        Relapses and progression of disability in multiple sclerosis.
        N Engl J Med. 1998; 338: 278-285
        • Romani A.
        • Bergamaschi R.
        • Candeloro E.
        • Alfonsi E.
        • Callieco R.
        • Cosi V.
        Fatigue in multiple sclerosis: multidimensional assessment and response to symptomatic treatment.
        Mult Scler. 2004; 10: 462-468
        • Rodgers M.M.
        • Mulcare J.A.
        • King D.L.
        • Mathews T.
        • Gupta S.C.
        • Glaser R.M.
        Gait characteristics of individuals with multiple sclerosis before and after a 6-month aerobic training program.
        J Rehabil Res Dev. 1999; 36: 183-188
        • Feys P.
        • Duportail M.
        • Kos D.
        • Van Asch P.
        • Ketelaer P.
        Validity of the TEMPA for the measurement of upper limb function in multiple sclerosis.
        Clin Rehabil. 2002; 16: 166-173
        • Leocani L.
        • Martinelli V.
        • Natali-Sora M.G.
        • Rovaris M.
        • Comi G.
        Somatosensory evoked potentials and sensory involvement in multiple sclerosis: comparison with clinical findings and quantitative sensory tests.
        Mult Scler. 2003; 9: 275-279
        • Krishnan V.
        • Jaric S.
        Hand function in multiple sclerosis: force coordination in manipulation tasks.
        Clin Neurophysiol. 2008; 119: 2274-2281
        • Lamers I.
        • Kerkhofs L.
        • Raats J.
        • Kos D.
        • Van Wijmeersch B.
        • Feys P.
        Perceived and actual arm performance in multiple sclerosis: relationship with clinical tests according to hand dominance.
        Mult Scler. 2013; 19: 1341-1348
        • Johansson S.
        • Ytterberg C.
        • Claesson I.M.
        • et al.
        High concurrent presence of disability in multiple sclerosis. Associations with perceived health.
        J Neurol. 2007; 254: 767-773
        • McDonald I.
        • Compston A.
        The symptoms and signs of multiple sclerosis.
        Curchill Livingstone, London2006
        • Kamm C.P.
        • Heldner M.R.
        • Vanbellingen T.
        • Mattle H.P.
        • Müri R.
        • Bohlhalter S.
        Limb apraxia in multiple sclerosis: prevalence and impact on manual dexterity and activities of daily living.
        Arch Phys Med Rehabil. 2012; 93: 1081-1085
        • Miller D.M.
        Health-related quality of life.
        Mult Scler. 2002; 8: 269-270
        • Kierkegaard M.
        • Einarsson U.
        • Gottberg K.
        • von Koch L.
        • Holmqvist L.W.
        The relationship between walking, manual dexterity, cognition and activity/participation in persons with multiple sclerosis.
        Mult Scler. 2012; 18: 639-646
        • Mark V.W.
        • Taub E.
        • Bashir K.
        • et al.
        Constraint-induced movement therapy can improve hemiparetic progressive multiple sclerosis. Preliminary findings.
        Mult Scler. 2008; 14: 992-994
        • Kalron A.
        • Greenberg-Abrahami M.
        • Gelav S.
        • Achiron A.
        Effects of a new sensory re-education training tool on hand sensibility and manual dexterity in people with multiple sclerosis.
        NeuroRehabilitation. 2013; 32: 943-948
        • Kamm C.P.
        • Mattle H.P.
        • Müri R.M.
        • et al.
        Home-based training to improve manual dexterity in patients with multiple sclerosis: a randomized controlled trial.
        Mult Scler. 2015; 21: 1546-1556
        • Pozzilli C.
        • Brunetti M.
        • Amicosante A.M.
        • et al.
        Home based management in multiple sclerosis: results of a randomised controlled trial.
        J Neurol Neurosurg Psychiatry. 2002; 73: 250-255
        • McDonald W.I.
        • Compston A.
        • Edan G.
        • et al.
        Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis.
        Ann Neurol. 2001; 50: 121-127
        • Kurtzke J.F.
        Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).
        Neurology. 1983; 33: 1444-1452
        • Pfeiffer E.
        A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients.
        J Am Geriatr Soc. 1975; 23: 433-441
        • Oxford Grice K.
        • Vogel K.A.
        • Le V.
        • Mitchell A.
        • Muniz S.
        • Vollmer M.A.
        Adult norms for a commercially available Nine Hole Peg Test for finger dexterity.
        Am J Occup Ther. 2003; 57: 570-573
        • Brosseau L.
        • Wolfson C.
        The inter-rater reliability and construct validity of the Funcional Independence Measure for multiple sclerosis subjects.
        Clin Rehabil. 1994; 8: 107-115
        • Schatz P.
        Encyclopedia of clinical neuropsychology.
        Springer Science, New York2011
        • Lyle R.C.
        A performance test for assessment of upper limb function in physical rehabilitation treatment and research.
        Int J Rehabil Res. 1981; 4: 483-492
        • Platz T.
        • Pinkowski C.
        • van Wijck F.
        • Kim I.H.
        • di Bella P.
        • Johnson G.
        Reliability and validity of arm function assessment with standardized guidelines for the Fugl-Meyer Test, Action Research Arm Test and Box and Block Test: a multicentre study.
        Clin Rehabil. 2005; 19: 404-411
        • Carpinella I.
        • Cattaneo D.
        • Bertoni R.
        • Ferrarin M.
        Robot training of upper limb in multiple sclerosis: comparing protocols with or without manipulative task components.
        IEEE Trans Neural Syst Rehabil Eng. 2012; 20: 351-360
        • Lamers I.
        • Kelchtermans S.
        • Baert I.
        • Feys P.
        Upper limb assessment in multiples sclerosis: a systematic review of outcome measures and their psychometric properties.
        Arch Phys Med Rehabil. 2014; 95: 1184-1200
        • Yozbatiran N.
        • Der-Yeghiaian L.
        • Cramer S.C.
        A standardized approach to performing the action research arm test.
        Neurorehabil Neural Repair. 2008; 22: 78-90
        • Gallus J.
        • Mathiowetz V.
        Test-retest reliability of the Purdue Pegboard for persons with multiple sclerosis.
        Am J Occup Ther. 2003; 57: 108-111
        • Paltamaa J.
        • West H.
        • Sarasoja T.
        • Wikström J.
        • Mälkiä E.
        Reliability of physical functioning measures in ambulatory subjects with MS.
        Physiother Res Int. 2005; 10: 93-109
        • Fess E.E.
        Clinical assessment recommendations.
        American Society of Hand Therapists, Chicago1992
        • Kesserling J.
        Neurorehabilitation in multiple sclerosis–what is the evidence-base?.
        J Neurol. 2004; 251: 25-29
        • Yozbatiran N.
        • Baskurt F.
        • Baskurt Z.
        • Ozakbas S.
        • Idiman E.
        Motor assessment of upper extremity function and its relation with fatigue, cognitive function and quality of life in multiple sclerosis patients.
        J Neurol Sci. 2006; 246: 117-122
        • Ko K.C.
        Effectiveness of rehabilitation for multiple sclerosis.
        Clin Rehabil. 1999; 13: 33-41
        • Iyengar V.
        • Santos M.J.
        • Ko M.
        • Aruin A.S.
        Grip force control in individuals with multiple sclerosis.
        Neurorehabil Neural Repair. 2009; 23: 855-861
        • Iyengar V.
        • Santos M.J.
        • Ko M.
        • Aruin A.S.
        Effect of contralateral finger touch on grip force control in individuals with multiple sclerosis.
        Clin Neurophysiol. 2009; 120: 626-631
        • Severijns D.
        • Lamers I.
        • Kerkhofs L.
        • Feys P.
        Hand grip fatigability in persons with multiple sclerosis according to hand dominance and disease progression.
        J Rehabil Med. 2015; 47: 154-160