To compare the measurement properties and responsiveness to change of the Patient Health Questionnaire-9 (PHQ-9), the Hopkins Symptom Checklist-20 (HSCL-20), and the Hamilton Depression Rating Scale (HAM-D) in people with spinal cord injury (SCI) diagnosed with major depressive disorder (MDD).
Secondary analysis of depression symptoms measured at 6 occasions over 12 weeks as part of a randomized controlled trial of venlafaxine XR for MDD in persons with SCI.
Outpatient and community settings.
Individuals (N=133) consented and completed the drug trial. Eligibility criteria were age at least 18 years, traumatic SCI, and diagnosis of MDD.
Main Outcome Measures
Patients completed the PHQ-9 and the HSCL-20 depression scales; clinical investigators completed the HAM-D and the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV) Dissociative Disorders, which was used as a diagnostic criterion measure.
All 3 instruments were improved with rating scale analysis. The HSCL-20 and the HAM-D contained items that misfit the underlying construct and that correlated weakly with the total scores. Removing these items improved the internal consistency, with floor effects increasing slightly. The HAM-D correlated most strongly with Structured Clinical Interview for DSM-IV Dissociative Disorders diagnoses. Improvement in depression was similar on all outcome measures in both treatment and control groups.
The psychometric properties of the revised depression instruments are more than adequate for routine use in adults with SCI and are responsive to clinical improvement. The PHQ-9 is the simplest instrument with measurement properties as good as or better than those of the other instruments and required the fewest modifications.
List of abbreviations:CGI (Clinical Global Impression), DSM-IV (Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition), HAM-D (Hamilton Depression Rating Scale), HSCL-20 (Hopkins Symptom Checklist-20), MDD (major depressive disorder), PGI (Patient Global Impression), PHQ-9 (Patient Health Questionnaire-9), SCI (spinal cord injury), SCID-D (Structured Clinical Interview for DSM-IV Dissociative Disorders)
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Published online: February 06, 2016
Supported by the Department of Education, National Institute on Disability and Rehabilitation Research (grant nos. H133A060107 and H133N110009) and by Pfizer Pharmaceuticals in the form of study drug (protocol no. 0600B1-4439).
© 2016 by the American Congress of Rehabilitation Medicine