Abstract
Objective
To investigate submaximal and maximal responses during maximal cardiopulmonary exercise
tests in subjects with Parkinson disease (PD).
Design
Cross-sectional.
Setting
A PD association.
Participants
A sample (N=68) of subjects with PD (n=48; mean age, 66±8y; modified Hoehn and Yahr
stage between 2 and 3; “on” state of medication) and age-matched controls without
PD (n=20; mean age, 64±9y).
Interventions
Maximal cardiopulmonary exercise test on a cycle ergometer.
Main Outcome Measures
Oxygen uptake (o2), systolic blood pressure (SBP), and heart rate assessed at rest, submaximal intensities
(ie, anaerobic threshold [AT] and respiratory compensation point), and maximal intensity
(peak exercise).
Results
Compared with control subjects, subjects with PD had lower o2, heart rate, and SBP at respiratory compensation point and peak exercise (o2: 14.6±3.6mL⋅kg⋅min vs 17.9±5.5mL⋅kg⋅min and 17.7±4.8mL⋅kg⋅min vs 21.5±6.6mL⋅kg⋅min;
heart rate: 119±17beats/min vs 139±12beats/min and 132±20beats/min vs 158±13beats/min;
SBP: 151±17mmHg vs 172±20mmHg and 166±21mmHg vs 187±24mmHg; P≤.05). They also had lower heart rate at AT (102±14beats/min vs 110±13beats/min; P≤.05), whereas o2 and SBP at this intensity were similar to those of control subjects.
Conclusions
Subjects with PD demonstrated blunted metabolic and cardiovascular responses to submaximal
and maximal exercise tests, especially at intensities above AT, which are in line
with autonomic disturbances present in patients with PD. Future studies need to determine
how this affects performance, participation, and responses of these patients to exercise
training at different intensities.
Keywords
List of abbreviations:
AT (anaerobic threshold), PD (Parkinson disease), RCP (respiratory compensation point), SBP (systolic blood pressure), V˙o2 (oxygen uptake), Vo2peak (peak oxygen uptake)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: January 09, 2016
Footnotes
Supported by the Brazilian Council for the Scientific and Technological Development (CNPQ; process 142017/2012-4) and the Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES; process 99999.010276/2014-09; Program with Academic Excellence).
Clinical Trial Registration No.: U111-1129-0762.
Disclosures: none.
Identification
Copyright
© 2016 The American Congress of Rehabilitation Medicine.
