Advertisement
Original research| Volume 97, ISSUE 2, P273-280, February 2016

Reducing Sitting Time After Stroke: A Phase II Safety and Feasibility Randomized Controlled Trial

Published:October 31, 2015DOI:https://doi.org/10.1016/j.apmr.2015.10.094

      Abstract

      Objective

      To test the safety, feasibility, and effectiveness of reducing sitting time in stroke survivors.

      Design

      Randomized controlled trial with attention-matched controls and blinded assessments.

      Setting

      Community.

      Participants

      Stroke survivors (N=35; 22 men; mean age, 66.9±12.7y).

      Interventions

      Four counseling sessions over 7 weeks with a message of sit less and move more (intervention group) or calcium for bone health (attention-matched control group).

      Main Outcome Measures

      Measures included safety (adverse events, increases in pain, spasticity, or fatigue) and feasibility (adherence to trial protocol). Secondary measures included time spent sitting (including in prolonged bouts ≥30min), standing, and stepping as measured by the thigh-worn inclinometer (7d, 24h/d protocol) and time spent in physical activity of at least moderate intensity as measured by a triaxial accelerometer. The Multimedia Activity Recall for Children and Adults was used to describe changes in use of time.

      Results

      Thirty-three participants completed the full protocol. Four participants reported falls during the intervention period with no other adverse events. From a baseline average of 640.7±99.6min/d, daily sitting time reduced on average by 30±50.6min/d (95% confidence interval [CI], 5.8–54.6) in the intervention group and 40.4±92.5min/d in the control group (95% CI, 13.0–93.8). Participants in both groups also reduced their time spent in prolonged sitting bouts (≥30min) and increased time spent standing and stepping.

      Conclusions

      Our protocol was both safe and feasible. Participants in both groups spent less time sitting and more time standing and stepping postintervention, but outcomes were not superior for intervention participants. Attention matching is desirable in clinical trials and may have contributed to the positive outcomes for control participants.

      Keywords

      List of abbreviations:

      CI (confidence interval), MARCA (Multimedia Activity Recall for Children and Adults), MVPA (moderate-to-vigorous physical activity)
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Archives of Physical Medicine and Rehabilitation
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Feigin V.L.
        • Forouzanfar M.H.
        • Krishnamurthi R.
        • et al.
        Global and regional burden of stroke during 1990–2010: findings from the Global Burden of Disease Study 2010.
        Lancet. 2014; 383: 245-255
        • Hardie K.
        • Hankey G.J.
        • Jamrozik K.
        • Broadhurst R.J.
        • Anderson C.
        Ten-year risk of first recurrent stroke and disability after first-ever stroke in the Perth Community Stroke Study.
        Stroke. 2004; 35: 731-735
        • O'Donnell M.J.
        • Xavier D.
        • Liu L.
        • et al.
        Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study.
        Lancet. 2010; 376: 112-123
        • Dempsey P.C.
        • Owen N.
        • Biddle S.J.
        • Dunstan D.W.
        Managing sedentary behavior to reduce the risk of diabetes and cardiovascular disease.
        Curr Diab Rep. 2014; 14: 522
        • Dunstan D.W.
        • Howard B.
        • Healy G.N.
        • Owen N.
        Too much sitting–a health hazard.
        Diabetes Res Clin Pract. 2012; 97: 368-376
        • English C.
        • Healy G.N.
        • Coates A.
        • Lewis L.
        • Olds T.
        • Bernhardt J.
        Sitting and activity time in people with stroke.
        Phys Ther. 2015 Jun 25; ([Epub ahead of print])
        • English C.
        • Manns P.J.
        • Tucak C.
        • Bernhardt J.
        Physical activity and sedentary behaviors in people with stroke living in the community: a systematic review.
        Phys Ther. 2014; 94: 185-196
        • Kunkel D.
        • Fitton C.
        • Burnett M.
        • Ashburn A.
        Physical inactivity post-stroke: a 3-year longitudinal study.
        Disabil Rehabil. 2015; 37: 304-310
        • Moore S.A.
        • Hallsworth K.
        • Plotz T.
        • Ford G.A.
        • Rochester L.
        • Trenell M.I.
        Physical activity, sedentary behaviour and metabolic control following stroke: a cross-sectional and longitudinal study.
        PLoS One. 2013; 8: e55263
        • Paul L.
        • Brewster S.
        • Wyke S.
        • et al.
        Physical activity profiles and sedentary behaviour in people following stroke: a cross-sectional study.
        Disabil Rehabil. 2015; : 1-6
        • Tieges Z.
        • Mead G.
        • Allerhand M.
        • et al.
        Sedentary behavior in the first year after stroke: a longitudinal cohort study with objective measures.
        Arch Phys Med Rehabil. 2015; 96: 15-23
        • Dunstan D.W.
        • Kingwell B.A.
        • Larsen R.
        • et al.
        Breaking up prolonged sitting reduces postprandial glucose and insulin responses.
        Diabetes Care. 2012; 35: 976-983
        • Matthews C.E.
        • Moore S.C.
        • Sampson J.
        • et al.
        Mortality benefits for replacing sitting time with different physical activities.
        Med Sci Sports Exerc. 2015; 47: 1833-1840
        • Healy G.N.
        • Eakin E.G.
        • Lamontagne A.D.
        • et al.
        Reducing sitting time in office workers: short-term efficacy of a multicomponent intervention.
        Prev Med. 2013; 57: 43-48
        • Martin A.
        • Fitzsimons C.
        • Jepson R.
        • et al.
        Interventions with potential to reduce sedentary time in adults: systematic review and meta-analysis.
        Br J Sports Med. 2015; 49: 1056-1063
        • Rubak S.
        • Sandbaek A.
        • Lauritzen T.
        • Christensen B.
        Motivational interviewing: a systematic review and meta-analysis.
        Br J Gen Pract. 2005; 55: 305-312
        • Nicholson S.L.
        • Donaghy M.
        • Johnston M.
        • et al.
        A qualitative theory guided analysis of stroke survivors' perceived barriers and facilitators to physical activity.
        Disabil Rehabil. 2014; 36: 1857-1868
        • Xinying P.X.
        • Noakes M.
        • Keogh J.
        Can a food frequency questionnaire be used to capture dietary intake data in a 4 week clinical intervention trial?.
        Asia Pac J Clin Nutr. 2004; 13: 318-323
        • Wardlaw J.M.
        • Dennis M.S.
        • Lindley R.I.
        • Sellar R.J.
        • Warlow C.P.
        The validity of a simple clinical classification of acute ischaemic stroke.
        J Neurol. 1996; 243: 274-279
        • Dong Y.
        • Sharma V.K.
        • Chan B.P.
        • et al.
        The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke.
        J Neurol Sci. 2010; 299: 15-18
        • Vercoulen J.H.
        • Swanink C.M.
        • Fennis J.F.
        • Galama J.M.
        • van der Meer J.W.
        • Bleijenberg G.
        Dimensional assessment of chronic fatigue syndrome.
        J Psychosom Res. 1994; 38: 383-392
        • Ganz D.A.
        • Higashi T.
        • Rubenstein L.Z.
        Monitoring falls in cohort studies of community-dwelling older people: effect of the recall interval.
        J Am Geriatr Soc. 2005; 53: 2190-2194
        • Lyden K.
        • Kozey Keadle S.L.
        • Staudenmayer J.W.
        • Freedson P.S.
        Validity of two wearable monitors to estimate breaks from sedentary time.
        Med Sci Sports Exerc. 2012; 44: 2243-2252
        • Taraldsen K.
        • Askim T.
        • Sletvold O.
        • et al.
        Evaluation of a body-worn sensor system to measure physical activity in older people with impaired function.
        Phys Ther. 2011; 91: 277-285
        • Gorman E.
        • Hanson H.M.
        • Yang P.H.
        • Khan K.M.
        • Liu-Ambrose T.
        • Ashe M.C.
        Accelerometry analysis of physical activity and sedentary behavior in older adults: a systematic review and data analysis.
        Eur Rev Aging Phys Act. 2014; 11: 35-49
        • Freedson P.S.
        • Melanson E.
        • Sirard J.
        Calibration of the Computer Science and Applications, Inc. accelerometer.
        Med Sci Sports Exerc. 1998; 30: 777-781
        • Gomersall S.R.
        • Olds T.S.
        • Ridley K.
        Development and evaluation of an adult use-of-time instrument with an energy expenditure focus.
        J Sci Med Sport. 2011; 14: 143-148
        • Foley L.S.
        • Maddison R.
        • Rush E.
        • Olds T.S.
        • Ridley K.
        • Jiang Y.
        Doubly labeled water validation of a computerized use-of-time recall in active young people.
        Metabolism. 2013; 62: 163-169
        • Jones T.M.
        • Dean C.M.
        • Hush J.M.
        • Dear B.F.
        • Titov N.
        A systematic review of the efficacy of self-management programs for increasing physical activity in community-dwelling adults with acquired brain injury (ABI).
        Syst Rev. 2015; 4: 51
        • Gillham S.
        • Endacott R.
        Impact of enhanced secondary prevention on health behaviour in patients following minor stroke and transient ischaemic attack: a randomized controlled trial.
        Clin Rehabil. 2010; 24: 822-830
        • Rimmer J.H.
        • Wang E.
        • Smith D.
        Barriers associated with exercise and community access for individuals with stroke.
        J Rehabil Res Dev. 2008; 45: 315-322
        • Boysen G.
        • Krarup L.H.
        • Zeng X.
        • et al.
        ExStroke Pilot Trial of the effect of repeated instructions to improve physical activity after ischaemic stroke: a multinational randomised controlled clinical trial.
        BMJ. 2009; 339: b2810
        • Touillet A.
        • Guesdon H.
        • Bosser G.
        • Beis J.M.
        • Paysant J.
        Assessment of compliance with prescribed activity by hemiplegic stroke patients after an exercise programme and physical activity education.
        Ann Phys Rehabil Med. 2010; 53: 257-265
        • Healy G.N.
        • Winkler E.A.
        • Owen N.
        • Anuradha S.
        • Dunstan D.W.
        Replacing sitting time with standing or stepping: associations with cardio-metabolic risk biomarkers.
        Eur Heart J. 2015; 36: 2643-2649
        • Larsen R.N.
        • Kingwell B.A.
        • Sethi P.
        • Cerin E.
        • Owen N.
        • Dunstan D.W.
        Breaking up prolonged sitting reduces resting blood pressure in overweight/obese adults.
        Nutr Metab Cardiovasc Dis. 2014; 24: 976-982
        • Pivarnik J.M.
        • Reeves M.J.
        • Rafferty A.P.
        Seasonal variation in adult leisure-time physical activity.
        Med Sci Sports Exerc. 2003; 35: 1004-1008
        • Storti K.L.
        • Pettee K.K.
        • Brach J.S.
        • Talkowski J.B.
        • Richardson C.R.
        • Kriska A.M.
        Gait speed and step-count monitor accuracy in community-dwelling older adults.
        Med Sci Sports Exerc. 2008; 40: 59-64