Study Impact/Highlights
- •To our knowledge, this is the first study to show that mildly disabled men with multiple sclerosis have significantly less brain activity in the thalamus and cerebellum during walking compared with women with multiple sclerosis, which may be unique to this patient population.
- •The suggestion that men may possess inherent, preclinical vulnerability to the neuropathologic processes of multiple sclerosis is not supported by the actual results, but it deserves to be tested in a larger sample of healthy subjects.
- •This study provides the feasibility and utility of positron emission tomography with fluorine-18-labeled deoxyglucose aimed at detecting brain region glucose uptake and activity during a physical performance task.
Abstract
Objective
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Main Outcome Measure
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List of abbreviations:
FDG (fluorine-18-labeled deoxyglucose), MS (multiple sclerosis), PET (positron emission tomography), SUV (standardized uptake value)Purchase one-time access:
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Article info
Publication history
Footnotes
Supported by the National Multiple Sclerosis Society (grant no. PP1907) and in part by the National Institutes of Health/National Center for Advancing Translational Sciences Colorado Clinical and Translational Sciences Institute (grant no. UL1 TR000154). North American Research Consortium on Multiple Sclerosis is supported in part by the Consortium of Multiple Sclerosis Centers (CMSC) and the CMSC Foundation.
Disclosures: none.