To investigate the effects of ultrasound-guided injections of hyaluronic acid (HA) versus steroid for trigger fingers in adults.
Prospective, double-blinded, randomized controlled study.
Tertiary care center.
Subjects with a diagnosis of trigger finger (N=36; 39 affected digits) received treatment and were evaluated.
Subjects were randomly assigned to HA and steroid injection groups. Both study medications were injected separately via ultrasound guidance with 1 injection.
Main Outcome Measures
The classification of trigger grading, pain, functional disability, and patient satisfaction were evaluated before the injection and 3 weeks and 3 months after the injection.
At 3 months, 12 patients (66.7%) in the HA group and 17 patients (89.5%) in the steroid group exhibited no triggering of the affected fingers (P=.124). The treatment results at 3 weeks and 3 months showed similar changes in the Quinnell scale (P=.057 and .931, respectively). A statistically significant interaction effect between group and time was found for visual analog scale (VAS) and Michigan Hand Outcome Questionnaire (MHQ) evaluation (P<.05). The steroid group had a lower VAS at 3 months after injection (steroid 0.5±1.1 vs HA 2.7±2.4; P<.001). The HA group demonstrated continuing significant improvement in MHQ at 3 months (change from 3wk: steroid −2.6±14.1 vs HA 19.1±37.0; P=.023; d=.78).
Ultrasound-guided injection of HA demonstrated promising results for the treatment of trigger fingers. The optimal frequency, dosage, and molecular weight of HA injections for trigger fingers deserve further investigation for future clinical applications.
List of abbreviations:DM (diabetes mellitus), HA (hyaluronic acid), MHQ (Michigan Hand Outcome Questionnaire), TAM (total active motion), UGI (ultrasound-guided injection), VAS (visual analog scale)
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Published online: September 01, 2015
Supported by the Ministry of Science and Technology (grant nos. 101-2627-B-075-001) from Ministry of Science and Technology, and by Taipei Veterans General Hospital (grant no. 101-X2-06).
Clinical Trial Registration No.: NCT01950793.
© 2015 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.