- •We examined cortical activation during an illusory walking paradigm in persons with spinal cord injury.
- •Persons with spinal cord injury showed activation in the somatosensory cortex.
- •Able-bodied persons showed activation in the premotor cortical areas.
To determine the location of cortical activation during a visual illusion walking paradigm, a recently proposed treatment for spinal cord injury (SCI)–related neuropathic pain, in persons with SCI compared with able-bodied controls.
Pilot experimental functional magnetic resonance imaging (fMRI) trial.
Outpatient rehabilitation clinic.
Persons with paraplegia (n=3) and able-bodied participants (n=5) were included in this study.
Main Outcome Measure
Cortical activation as measured by the blood oxygenation level-dependent method of fMRI.
During visually illusory walking there was significant activation in the somatosensory cortex among those with SCI. In contrast, able-bodied participants showed little to no significant activation in this area, but they showed activation in the frontal and premotor areas.
Treatment modalities for SCI-related neuropathic pain that are based on sensory input paradigms (eg, virtual walking, visual illusory walking) may work by targeting the somatosensory cortex, an area that has been previously found to functionally reorganize after SCI.
List of abbreviations:fMRI (functional magnetic resonance imaging), SCI (spinal cord injury)
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Published online: November 14, 2014
Supported by the Rehabilitation Research Experience for Medical Students Program of the Association of Academic Physiatrists; National Institute on Disability and Rehabilitation Research (grant no. H133N110008); and National Institutes of Health (grant no. 1 K23 HD073680-01A1).
© 2015 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.