To investigate the changes in muscle oxygen consumption (mO2) using near-infrared spectroscopy (NIRS) after 4 weeks of training with functional electrical stimulation (FES) cycling in nonambulatory people with multiple sclerosis (MS).
Four-week before-after trial to assess changes in mO2 after an FES cycling intervention.
People (N=8; 7 men, 1 women) from a volunteer/referred sample with moderate to severe MS (Expanded Disability Status Scale score>6.0).
Participants cycled 30 minutes per session, 3d/wk for 4 weeks or a total of 12 sessions.
Main Outcome Measures
mO2 of the right vastus lateralis muscle was measured with NIRS before and within 1 week after the intervention. Six bouts of 15-second electrical stimulation increasing from 2 to 7Hz were used to activate the muscle. mO2 was assessed by analyzing the slope of the NIRS oxygen signal during a 10-second arterial occlusion after each electrical stimulation bout.
Significant FES training by electrical stimulation frequency level interaction was observed (P=.031), with an average increase in mO2 of 47% across frequencies with a main effect of training (P=.047).
FES cycling for 4 weeks improved mO2, suggesting that FES cycling is a potential therapy for improving muscle health in people with MS who are nonambulatory.
List of abbreviations:FES (functional electrical stimulation), MS (multiple sclerosis), mV˙O2 (muscle oxygen consumption), NIRS (near-infrared spectroscopy), 31P-MRS (31 phosphorous magnetic resonance spectroscopy), RPM (revolutions per minute)
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Published online: November 03, 2014
Supported by the Eula C. and Andrew C. Carlos Multiple Sclerosis Rehabilitation and Wellness Program at the Shepherd Center.
© 2015 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.