Highlights
- •Resistance training increases muscle strength in prostate cancer survivors on androgen deprivation therapy.
- •Resistance training improved self-report physical function and lessened disability.
- •Increases in muscle strength likely contributed to reductions in disability.
Abstract
Objectives
To investigate whether functionally based resistance exercise could improve strength,
physical function, and disability among prostate cancer survivors (PCS) on androgen
deprivation therapy (ADT); and to explore potential mediators of changes in outcomes
from exercise.
Design
Randomized controlled trial.
Setting
Academic medical center.
Participants
PCS (N=51; mean age, 70.2y) on ADT.
Intervention
PCS were randomized to moderate to vigorous intensity resistance training or stretching
(placebo control) for 1 year.
Main Outcome Measures
Maximal leg press and bench press strength, objective and self-reported physical function,
and self-reported disability. Hierarchical linear modeling was used to test for significant
group × time differences adjusting for covariates.
Results
Retention in the study was 84%, and median attendance to supervised classes was 84%
in the resistance group. No study-related injuries occurred. Maximal leg strength
(P=.032) and bench press strength (P=.027) were improved after 1 year of resistance training, whereas little change occurred
from stretching. Self-reported physical function improved with resistance training,
whereas decreases occurred from stretching (P=.016). Disability lessened more with resistance training than stretching (P=.018). One-year change in leg press strength mediated the relation between groups
(resistance or stretching) and 1-year change in self-reported disability (P<.05).
Conclusions
One year of resistance training improved muscle strength in androgen-deprived PCS.
Strengthening muscles using functional movement patterns may be an important feature
of exercise programs designed to improve perceptions of physical function and disability.
Findings from this study contribute to the mounting evidence that exercise should
become a routine part of clinical care in older men with advanced prostate cancer.
Keywords
List of abbreviations:
ADT (androgen deprivation therapy), FLEX (placebo control program of seated stretching exercise), ITT (intention-to-treat), LLFDI (Late-Life Function and Disability Instrument), PCS (prostate cancer survivors), POWIR (Prevent Osteoporosis with Impact + Resistance), PPB (Physical Performance Battery)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: September 03, 2014
Footnotes
Supported by the Livestrong Foundation (formerly Lance Armstrong Foundation); and TheraBand, Inc, for providing elastic exercise bands for study participants.
Clinical Trial Registration No.: NCT00660686.
Disclosures: none.
Identification
Copyright
© 2015 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
