The Multiple Sclerosis Impact Scale (MSIS-29) is a 29-item self-report measure comprised
of 20 items associated with a physical scale and 9 items associated with a psychological
scale.1 Items question patients (or their proxies) about the impact of multiple sclerosis
(MS) on day-to-day life in the last 2 weeks. All items have 5 response options from
1 (not at all) to 5 (extremely). Each of the 2 scales are scored by summing the responses
across items, then converting to a 0 to 100 scale, where 100 indicates greater impact
of disease on daily function (worse health). The items were selected via a standardized
psychometric process: generating a large item pool from patient interviews and professional
judgment, then winnowing down to the current items based on pilot and field testing.1 Reliability and validity evidence have been obtained in multiple samples of people
with MS from disability levels of 0 to 9.5 on the Expanded Disability Status Scale.
The MSIS-29 is responsive to intervention, with a change score of about 8 on the physical
scale or about 6 on the psychological scale having moderate to high sensitivity and
specificity for patients, indicating whether they had improved or not. A 7-member
MS Outcome Measure Task Force of the neurology section of the American Physical Therapy
Association highly recommends this measure for use in this population across disability
levels and practice settings (http://neuropt.org/go/healthcare-professionals/neurology-section-outcome-measures-recommendations/multiple-sclerosis).
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Footnotes
This content is provided as a service by the American Congress of Rehabilitation Medicine and is not peer reviewed by the Archives.