Abstract
Objective
To examine the impact of a muscle resistance program (MRP) on muscular and functional
performance and on interleukin 6 (IL-6) and soluble tumor necrosis factor receptor-1
(sTNFr1) plasma levels in prefrail community-dwelling women.
Design
Randomized controlled trial crossover design with a postintervention and short-term
follow-up.
Setting
University hospital.
Participants
Prefrail community-dwelling women (N=32; ≥65y).
Intervention
The MRP was designed based on the exercise at 75% of each participant's maximum load
(10wk, 3 times/wk).
Main Outcome Measures
Plasma concentrations of IL-6 and sTNFr1 (high-sensitivity enzyme-linked immunosorbent
assay kits), muscle strength of the knee extensors (isokinetic), and functional performance
(Timed Up & Go [TUG] test and 10-meter walk test [10MWT]).
Results
There were significant differences in functional and muscular performance between
the pre-MRP, post-MRP, and 10-week follow-up period. After the MRP, both functional
(TUG, pre-MRP=11.1s vs post-MRP=10.4s, P=.00; 10MWT, pre-MRP=4.9s vs post-MRP, 4.4s, P=.00) and muscular performances (pre-MRP=77.8% and post-MRP=83.1%, P=.02) improved. After cessation of the MRP (follow-up period), sTNFr1 plasma levels
increased by 21.4% at 10-week follow-up (post-MRP, 406.4pg/mL; 10-week follow-up,
517.0pg/mL; P=.03). There were significant differences in sTNFr1 (P=.01).
Conclusions
The MRP was effective in improving functional and muscular performances, although
alterations in plasma levels of IL-6 and sTNFr1 could not be identified after the
MRP. Cessation of the MRP after 10 weeks resulted in increased plasma levels of sTNFr1.
Keywords
List of abbreviations:
ANOVA (analysis of variance), CG (control group), IL-6 (interleukin 6), MRP (muscle resistance program), sTNFr1 (soluble tumor necrosis factor receptor-1), 10MWT (10-meter walk test), TNF-α (tumor necrosis factor-alpha), TUG (Timed Up & Go)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: November 19, 2012
Footnotes
Supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico and Fundação de Amparo à Pesquisa do Estado de Minas Gerais.
No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit on the authors or on any organization with which the authors are associated.
Identification
Copyright
© 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
