Original article| Volume 94, ISSUE 4, P660-666, April 2013

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Impact of an Exercise Program on Muscular and Functional Performance and Plasma Levels of Interleukin 6 and Soluble Receptor Tumor Necrosis Factor in Prefrail Community-Dwelling Older Women: A Randomized Controlled Trial

Published:November 19, 2012DOI:



      To examine the impact of a muscle resistance program (MRP) on muscular and functional performance and on interleukin 6 (IL-6) and soluble tumor necrosis factor receptor-1 (sTNFr1) plasma levels in prefrail community-dwelling women.


      Randomized controlled trial crossover design with a postintervention and short-term follow-up.


      University hospital.


      Prefrail community-dwelling women (N=32; ≥65y).


      The MRP was designed based on the exercise at 75% of each participant's maximum load (10wk, 3 times/wk).

      Main Outcome Measures

      Plasma concentrations of IL-6 and sTNFr1 (high-sensitivity enzyme-linked immunosorbent assay kits), muscle strength of the knee extensors (isokinetic), and functional performance (Timed Up & Go [TUG] test and 10-meter walk test [10MWT]).


      There were significant differences in functional and muscular performance between the pre-MRP, post-MRP, and 10-week follow-up period. After the MRP, both functional (TUG, pre-MRP=11.1s vs post-MRP=10.4s, P=.00; 10MWT, pre-MRP=4.9s vs post-MRP, 4.4s, P=.00) and muscular performances (pre-MRP=77.8% and post-MRP=83.1%, P=.02) improved. After cessation of the MRP (follow-up period), sTNFr1 plasma levels increased by 21.4% at 10-week follow-up (post-MRP, 406.4pg/mL; 10-week follow-up, 517.0pg/mL; P=.03). There were significant differences in sTNFr1 (P=.01).


      The MRP was effective in improving functional and muscular performances, although alterations in plasma levels of IL-6 and sTNFr1 could not be identified after the MRP. Cessation of the MRP after 10 weeks resulted in increased plasma levels of sTNFr1.


      List of abbreviations:

      ANOVA (analysis of variance), CG (control group), IL-6 (interleukin 6), MRP (muscle resistance program), sTNFr1 (soluble tumor necrosis factor receptor-1), 10MWT (10-meter walk test), TNF-α (tumor necrosis factor-alpha), TUG (Timed Up & Go)
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