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Department Letter to the Editor| Volume 93, ISSUE 10, P1883-1884, October 2012

The Authors Respond

      We appreciate the comments from Morone et al on our article.
      • Dalgas U.
      • Severinsen K.
      • Overgaard K.
      Relations between 6 minute walking distance and 10 meter walking speed in patients with multiple sclerosis and stroke.
      We agree that there may be aspects that are not revealed by a correlation coefficient and that an analysis of the residuals may provide further insights. Our article already provides a figure showing linear regression lines based on the individual data points. As suggested in Morone's letter, we have now further created residual plots to look at whether the variations in residuals plotted against the predicted walking speed are systematic or not. As shown in figure 1, the variations in residuals are nonsystematic in our group of stroke patients. In the multiple sclerosis (MS) patients, the residual plot bears a slight resemblance to an inverted U-shape, indicating that the relation between the 2 tests might be better represented by a curvilinear model. However, fitting to a second-order polynomial instead of a linear regression would only minimally increase the predictive power of the fit (r=.97 vs .95). The residuals of the control group do not seem to vary systematically.
      Figure thumbnail gr1
      Fig 1Residual plots showing individual differences between measured 6MWT speed and 6MWT speed predicted from linear regression between the 10mWT and 6MWT tests. Stroke patients, MS patients, and controls are shown separately. For details on subjects and methods see the Dalgas et al article.
      • Dalgas U.
      • Severinsen K.
      • Overgaard K.
      Relations between 6 minute walking distance and 10 meter walking speed in patients with multiple sclerosis and stroke.
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      References

        • Dalgas U.
        • Severinsen K.
        • Overgaard K.
        Relations between 6 minute walking distance and 10 meter walking speed in patients with multiple sclerosis and stroke.
        Arch Phys Med Rehabil. 2012; 93: 1167-1172
        • ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories
        ATS statement: guidelines for the six-minute walk test.
        Am J Respir Crit Care Med. 2002; 166: 111-117
        • Kieseier B.C.
        • Pozzilli C.
        Assessing walking disability in multiple sclerosis.
        Mult Scler. 2012; 18: 914-924

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