In response to Namazi's letter, we want to comment that the recent evidence on the positive effects of low-intensity pulsed ultrasound (LIPUS) over the regulation of the proinflammatory interleukin 1 (IL1) verifies the validity of the mechanotransduction theory. This cellular theory explains how living cells convert mechanical stimulus into biochemical responses through a complex process mediated by a large number of extracellular and intracellular structures, such as stretch-activated ion channels and integrins.
1The down regulation of IL1, observed by Tsuang et al,
- Ingber D.E.
Cellular mechanotransduction: putting all the pieces together again.
FASEB J. 2006; 20: 811-827
2can be considered a result of the mechanical stimulation of the cell and its extracellular matrix. This evidence supports the theoretical assumption that LIPUS therapy stimulates the cartilage repair process, stressing the importance of continuing with this line of research, specifically for the development of a disease-modifying treatment for osteoarthritis (OA).
- Tsuang Y.H.
- Liao L.W.
- Chao Y.H.
- et al.
Effects of low intensity pulsed ultrasound on rat Schwann cells metabolism.
Artif Organs. 2011; 35: 373-383
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Archives of Physical Medicine and Rehabilitation
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Cellular mechanotransduction: putting all the pieces together again.FASEB J. 2006; 20: 811-827
- Effects of low intensity pulsed ultrasound on rat Schwann cells metabolism.Artif Organs. 2011; 35: 373-383
© 2012 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
ScienceDirectAccess this article on ScienceDirect
- Effect of Low-Intensity Pulsed Ultrasound on the Cartilage Repair in People With Mild to Moderate Knee Osteoarthritis: A Novel Molecular MechanismArchives of Physical Medicine and RehabilitationVol. 93Issue 10
- PreviewI read with great interest the article by Loyola-Sánchez et al1 regarding the effect of low-intensity pulsed ultrasound (LIPUS) on the cartilage repair in osteoarthritis. I would like to complete the discussion of Loyola-Sánchez by introducing a major route in which LIPUS could repair cartilage in osteoarthritis.