In response to Namazi's letter, we want to comment that the recent evidence on the
positive effects of low-intensity pulsed ultrasound (LIPUS) over the regulation of
the proinflammatory interleukin 1 (IL1) verifies the validity of the mechanotransduction
theory. This cellular theory explains how living cells convert mechanical stimulus
into biochemical responses through a complex process mediated by a large number of
extracellular and intracellular structures, such as stretch-activated ion channels
and integrins.
1
The down regulation of IL1, observed by Tsuang et al,
2
can be considered a result of the mechanical stimulation of the cell and its extracellular
matrix. This evidence supports the theoretical assumption that LIPUS therapy stimulates
the cartilage repair process, stressing the importance of continuing with this line
of research, specifically for the development of a disease-modifying treatment for
osteoarthritis (OA).To read this article in full you will need to make a payment
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References
- Cellular mechanotransduction: putting all the pieces together again.FASEB J. 2006; 20: 811-827
- Effects of low intensity pulsed ultrasound on rat Schwann cells metabolism.Artif Organs. 2011; 35: 373-383
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© 2012 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
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Access this article on ScienceDirectLinked Article
- Effect of Low-Intensity Pulsed Ultrasound on the Cartilage Repair in People With Mild to Moderate Knee Osteoarthritis: A Novel Molecular MechanismArchives of Physical Medicine and RehabilitationVol. 93Issue 10
- PreviewI read with great interest the article by Loyola-Sánchez et al1 regarding the effect of low-intensity pulsed ultrasound (LIPUS) on the cartilage repair in osteoarthritis. I would like to complete the discussion of Loyola-Sánchez by introducing a major route in which LIPUS could repair cartilage in osteoarthritis.
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