I read with great interest the article by Loyola-Sánchez et al
1regarding the effect of low-intensity pulsed ultrasound (LIPUS) on the cartilage repair in osteoarthritis. I would like to complete the discussion of Loyola-Sánchez by introducing a major route in which LIPUS could repair cartilage in osteoarthritis.
- Loyola-Sánchez A.
- Richardson J.
- Beattie K.A.
- Otero-Fuentes C.
- Adachi J.D.
- MacIntyre N.J.
Effect of low-intensity pulsed ultrasound on the cartilage repair in people with mild to moderate knee osteoarthritis: a double-blinded, randomized, placebo-controlled pilot study.
Arch Phys Med Rehabil. 2012; 93: 35-42
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- Effect of low-intensity pulsed ultrasound on the cartilage repair in people with mild to moderate knee osteoarthritis: a double-blinded, randomized, placebo-controlled pilot study.Arch Phys Med Rehabil. 2012; 93: 35-42
- Haem oxygenase-1 counteracts the effects of interleukin-1β on inflammatory and senescence markers in cartilage-subchondral bone explants from osteoarthritic patients.Clin Sci (Lond). 2012; 122: 239-250
- Effects of low intensity pulsed ultrasound on rat Schwann cells metabolism.Artif Organs. 2011; 35: 373-383
© 2012 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
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- The Authors RespondArchives of Physical Medicine and RehabilitationVol. 93Issue 10
- PreviewIn response to Namazi's letter, we want to comment that the recent evidence on the positive effects of low-intensity pulsed ultrasound (LIPUS) over the regulation of the proinflammatory interleukin 1 (IL1) verifies the validity of the mechanotransduction theory. This cellular theory explains how living cells convert mechanical stimulus into biochemical responses through a complex process mediated by a large number of extracellular and intracellular structures, such as stretch-activated ion channels and integrins.