Abstract
Whyte J, Barrett AM. Advancing the evidence base of rehabilitation treatments: a developmental
approach.
Translational research refers to the development of new scientific discoveries into
evidence-based treatments for human diseases and conditions. This developmental process
requires that a number of scientific, as well as social and psychological obstacles,
be overcome during a sequence of research stages that address different goals. Rehabilitation,
like other biomedical disciplines, requires this kind of developmental process. For
a variety of reasons, however, development of rehabilitation treatments is less linear
than the familiar phases of pharmaceutical research. In addition, research on treatments
intended to address impairments (body structure/function, in terms of the International Classification of Functioning, Disability and Health), faces the challenge of determining the likely impact of an impairment-level treatment
on the multifaceted activities and aspects of participation that are the typical goals
of rehabilitation treatments. This article describes the application of treatment
theory and enablement theory to the development of new impairment-based treatments,
and examines similarities and differences between the developmental sequence needed
for rehabilitation treatment research versus pharmaceutical research in other areas
of medicine.
Key Words
List of Abbreviations:
APT (attention process training), CIMT (constraint-induced movement therapy), ICF (International Classification of Functioning, Disability and Health), RCT (randomized controlled trial), TBI (traumatic brain injury)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: June 11, 2012
Footnotes
Supported in part by the National Institutes of Health (grant nos. HD050836 and HD062647) and National Institute on Disability and Rehabilitation Research (cooperative agreement no. H133A080053).
No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit on the authors or on any organization with which the authors are associated.
In-press corrected proof published online on Jun 7, 2012, at www.archives-pmr.org.
Identification
Copyright
© 2012 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
