Abstract
Manley GT, Diaz-Arrastia R, Brophy M, Engel D, Goodman C, Gwinn K, Veenstra TD, Ling
G, Ottens AK, Tortella F, Hayes RL. Common data elements for traumatic brain injury:
recommendations from the Biospecimens and Biomarkers Working Group.
Recent advances in genomics, proteomics, and biotechnology have provided unprecedented
opportunities for translational research and personalized medicine. Human biospecimens
and biofluids represent an important resource from which molecular data can be generated
to detect and classify injury and to identify molecular mechanisms and therapeutic
targets. To date, there has been considerable variability in biospecimen and biofluid
collection, storage, and processing in traumatic brain injury (TBI) studies. To realize
the full potential of this important resource, standardization and adoption of best
practice guidelines are required to insure the quality and consistency of these specimens.
The aim of the Biospecimens and Biomarkers Working Group was to provide recommendations
for core data elements for TBI research and develop best practice guidelines to standardize
the quality and accessibility of these specimens. Consensus recommendations were developed
through interactions with focus groups and input from stakeholders participating in
the interagency workshop on Standardization of Data Collection in TBI and Psychological
Health held in Washington, DC, in March 2009. With the adoption of these standards
and best practices, future investigators will be able to obtain data across multiple
studies with reduced costs and effort and accelerate the progress of genomic, proteomic,
and metabolomic research in TBI.
Key Words
List of Abbreviations:
APOE-e4 (apolipoprotein E4), CDE (common data element), COMT (catechol O-methyltransferase), DNA (deoxyribonucleic acid), EDTA (ethylenediaminetetraacetic acid), EVD (external ventricular drain), LP (lumbar puncture), PBMC (peripheral blood mononuclear cell), RBC (red blood cell), TBI (traumatic brain injury)To read this article in full you will need to make a payment
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Article info
Footnotes
A commercial party having a direct financial interest in the results of the research supporting this article has conferred or will confer a financial benefit on the author or one or more of the authors. R. L. Hayes is founder and president of Banyan Biomarkers Inc.
The views, opinions, or assertions contained herein are the private views of the authors and do not necessarily reflect those of the agencies or institutions with which they are affiliated, including the U.S. Department of Veterans Affairs, U.S. Department of Defense, Department of the Army, the U.S. Department of Health and Human Services, the National Institutes of Health, the National Institute of Mental Health, and the Uniformed Services University of the Health Sciences. This work is not an official document, guidance, or policy of the U.S. Government, nor should any official endorsement be inferred.
Reprints are not available from the author.
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Published by Elsevier Inc.
