Rietberg MB, van Wegen EE, Uitdehaag BM, de Vet HC, Kwakkel G. How reproducible is home-based 24-hour ambulatory monitoring of motor activity in patients with multiple sclerosis?
To determine the reproducibility of 24-hour monitoring of motor activity in patients with multiple sclerosis (MS).
Test-retest design; 6 research assistants visited the participants twice within 1 week in the home situation.
A convenience sample of ambulatory patients (N=43; mean age ± SD, 48.7±7.0y; 30 women; median Expanded Disability Status Scale scores, 3.5; interquartile range, 2.5) were recruited from the outpatient clinic of a university medical center.
Main Outcome Measures
Dynamic activity and static activity parameters were recorded by using a portable data logger and classified continuously for 24 hours. Reproducibility was determined by calculating intraclass correlation coefficients (ICCs) for test-retest reliability and by applying the Bland-Altman method for agreement between the 2 measurements. The smallest detectable change (SDC) was calculated based on the standard error of measurement.
Test-retest reliability expressed by the ICCagreement was .72 for dynamic activity, .74 for transitions, .77 for walking, .71 for static activity, .67 for sitting, .62 for standing, and .55 for lying. Bland and Altman analysis indicated no systematic differences between the first and second assessment for dynamic and static activity. Measurement error expressed by the SDC was 1.23 for dynamic activity, 66 for transitions, .99 for walking, 1.52 for static activity, 4.68 for lying, 3.95 for sitting, and 3.34 for standing.
The current study shows that with 24-hour monitoring, a reproducible estimate of physical activity can be obtained in ambulatory patients with MS.
List of Abbreviations:ADLs (activities of daily living), AM (activity monitor), EDSS (Expanded Disability Status Scale), ICC (intraclass correlation coefficient), IQR (interquartile range), LoA (limit of agreement), MS (multiple sclerosis), SDC (smallest detectable change), SEM (standard error of the mean)
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Supported by Stichting MS Research (project no. 04-553 MS).
No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit on the authors or on any organization with which the authors are associated.
Reprints are not available from the author.
© 2010 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.