Exploratory Study on Oxygen Consumption On-kinetics During Treadmill Walking in Women With Systemic Lupus Erythematosus


      Keyser RE, Rus V, Mikdashi JA, Handwerger BS. Exploratory study on oxygen consumption on-kinetics during treadmill walking in women with systemic lupus erythematosus.


      To determine whether oxygen consumption (V˙o2) on-kinetics differed between groups of women with systemic lupus erythematosus (SLE) and sedentary but otherwise healthy controls.


      Exploratory case-control study.


      Medical school exercise physiology laboratory.


      Convenience samples of women with SLE (n=12) and sedentary but otherwise healthy controls (n=10).



      Main Outcome Measures

      o2 on-kinetics indices including time to steady state, rate constant, mean response time (MRT), transition constant, and oxygen deficit measured during bouts of treadmill walking at intensities of 3 and 5 metabolic equivalents (METs).


      Time to steady state and oxygen deficit were increased and rate constant was decreased in the women with SLE compared with controls. At the 5-MET energy demand, the transition constant was lower and MRT was longer in the women with SLE than in controls. For a similar relative energy expenditure that was slightly lower than the anaerobic threshold, the transition constant was higher in controls than in women with SLE.


      o2 on-kinetics was prolonged in women with SLE. The prolongation was concomitant with an increase in oxygen deficit and may underlie performance fatigability in women with SLE.

      Key Words

      List of Abbreviations:

      ANCOVA (analysis of covariance), ANOVA (analysis of variance), a-vo2 (arteriovenous oxygen difference), CI (confidence interval), METs (metabolic equivalents), MRT (mean response time), RER (respiratory exchange ratio), SLE (systemic lupus erythematosus), ΔV˙o2 (amplitude of oxygen consumption increase at the sixth minute of exercise), Qt (maximum cardiac output), V˙o2 (oxygen consumption), Vo2peak (peak oxygen consumption)
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