Abstract
Liu C, Latham N. Adverse events reported in progressive resistance strength training
trials in older adults: 2 sides of a coin.
Objectives
To summarize adverse events reported in randomized controlled trials that applied
progressive resistance strength training in older adults and to examine factors that
might be associated with these events.
Design
After systematic searches of databases, 2 reviewers independently screened and extracted
adverse event–related information from identified trials.
Setting
Not applicable.
Participants
Older adults 60 years of age and above (N = 6700).
Intervention
Muscle strength training exercise that increases load gradually.
Main Outcome Measures
Adverse events and reasons for dropout. Adverse events include any undesirable outcomes
that may be directly related or unrelated to the intervention.
Results
Among 121 trials identified, 53 trials provided no comments about adverse events,
25 trials reported no adverse events occurred, and 43 trials reported some types of
adverse events. Most adverse events reported were musculoskeletal problems such as
muscle strain or joint pain. Adverse events were reported more often in trials that
recruited participants with certain health conditions, functional limitations, or
sedentary lifestyle; in trials that applied high intensity; and in trials that were
published after the 2001 Consolidated Standards of Reporting Trials statement had
been published. Reasons reported for dropout in 58 trials might be related to adverse
events. The most frequent reasons for dropout were illness or medical problems.
Conclusions
Adverse events may be underreported because there is no consensus on the definition.
Reporting adverse events associated with progressive resistance strength training
in older adults is informative for practitioners to translate clinical research to
clinical practice by knowing both the benefits and risks. Future trials should clearly
define adverse events and report them in the published article.
Key Words
List of Abbreviations:
AE (adverse event), CONSORT (Consolidated Standards of Reporting Trials)To read this article in full you will need to make a payment
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References
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Article info
Footnotes
Supported by the National Institute on Disability and Rehabilitation Research (postdoctoral fellowship grant no. H133P001) to Boston University.
No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit on the authors or on any organization with which the authors are associated.
Identification
Copyright
© 2010 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
